In the intricate world of pharmaceutical chemistry, certain molecules serve as foundational elements for life-saving drugs. 2-Chloro-3-amino-4-methylpyridine (CAS: 133627-45-9) is one such critical intermediate. Its primary role as a precursor in the synthesis of Nevirapine, a vital antiretroviral medication, underscores its importance. For R&D chemists, process engineers, and procurement specialists, understanding this compound's characteristics and its place in the pharmaceutical supply chain is key.

Chemical Identity and Properties

2-Chloro-3-amino-4-methylpyridine is a pyridine derivative with the molecular formula C6H7ClN2. Its structure features a pyridine ring substituted with a chlorine atom, an amino group, and a methyl group. Physically, it is often described as a yellowish powder with a purity typically exceeding 99.0%. Its melting point generally falls between 61-64°C, and it has a density of approximately 1.26 g/cm³. These properties are crucial for handling, storage, and reaction planning within a chemical manufacturing environment.

Significance in Nevirapine Synthesis

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination therapy to treat HIV-1 infection. The synthesis of Nevirapine is a complex process where 2-Chloro-3-amino-4-methylpyridine acts as a core building block. The specific arrangement of its substituents on the pyridine ring makes it ideally suited for the subsequent chemical transformations required to construct the Nevirapine molecule. The demand for Nevirapine directly drives the need for reliable, high-quality sources of this intermediate.

Sourcing and Quality Assurance for Pharmaceutical Buyers

Procurement managers looking to buy 2-Chloro-3-amino-4-methylpyridine must prioritize suppliers who demonstrate a strong commitment to quality and consistency. Key factors include:

  • High Purity: Ensuring ≥99.0% purity minimizes side reactions and improves the yield and quality of the final API.
  • Stable Supply: Partnering with manufacturers like NINGBO INNO PHARMCHEM CO., LTD., who have robust production capabilities, guarantees consistent availability.
  • Regulatory Compliance: Suppliers should be able to provide essential documentation, including Certificates of Analysis (CoA), to meet pharmaceutical industry standards.
  • Competitive Pricing: Obtaining quotes from multiple manufacturers, especially those in established chemical production hubs, is essential for cost optimization.

The role of 2-Chloro-3-amino-4-methylpyridine as a pharmaceutical intermediate highlights the critical link between basic chemical manufacturing and advanced drug production. By understanding its chemical profile and focusing on reliable sourcing, the pharmaceutical industry can ensure the continuous availability of essential medications.