In the realm of fine chemicals and pharmaceutical synthesis, understanding the specific properties and applications of key intermediates is crucial for efficient research and development. One such compound that has gained prominence is 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, readily identified by its CAS number 1256584-80-1. This complex organic molecule serves as a critical building block, particularly in the synthesis of advanced pharmaceutical agents.

Chemical Identity and Properties

The compound, 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, possesses a distinctive benzocarbazole fused ring system, further functionalized with an ethyl group, an iodine atom at the 8-position, and a nitrile group at the 3-position. Its molecular formula is C21H17IN2O, and it has a molecular weight of approximately 440.28 g/mol. Typically, this intermediate is supplied as a white powder, with a high purity level, often specified at 98%. These characteristics make it suitable for a wide array of chemical reactions and synthesis pathways, where precision and purity are paramount.

Significance in Pharmaceutical Synthesis

The primary driver for the demand of CAS 1256584-80-1 is its indispensable role as an intermediate in the production of Alectinib. Alectinib is a highly effective tyrosine kinase inhibitor that targets Anaplastic Lymphoma Kinase (ALK) and is used in the treatment of specific types of non-small cell lung cancer (NSCLC). The development of targeted therapies like Alectinib has revolutionized cancer treatment, and the availability of high-quality intermediates is fundamental to their production. Therefore, pharmaceutical companies and contract research organizations (CROs) actively seek reliable manufacturers and suppliers capable of consistently delivering this compound. Procurement managers often look for suppliers who can provide detailed technical specifications, including NMR and HPLC data, alongside Certificates of Analysis (CoA) to ensure the quality meets stringent pharmaceutical standards. Purchasing this intermediate from a reputable manufacturer in China can offer advantages in terms of cost and scalability.

Procurement and Supply Chain Considerations

For organizations needing to buy 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, several factors are important for a successful transaction. Identifying suppliers with robust quality management systems, competitive pricing for bulk orders, and flexible payment terms (e.g., T/T, L/C, PayPal) is key. Furthermore, understanding shipping logistics, including incoterms (FOB, CIF) and typical ports of export (e.g., Shanghai, Qingdao), helps in planning inventory and production timelines. The ability of a supplier to offer custom synthesis or scale-up services can also be a significant advantage for companies with evolving project requirements. Establishing a strong relationship with a trusted manufacturer ensures a stable supply chain for this critical chemical building block, supporting the ongoing innovation in targeted cancer therapies.