In the intricate world of pharmaceutical development, the efficiency and success of synthesizing complex Active Pharmaceutical Ingredients (APIs) are heavily reliant on the quality and availability of key intermediates. For researchers and formulators working with targeted therapies, especially those addressing oncological conditions, understanding the properties and sourcing of critical building blocks is paramount. 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, identified by its CAS number 1256584-80-1, stands out as a vital component in this landscape. As a high-purity intermediate, it plays a crucial role in the streamlined and effective synthesis of advanced pharmaceuticals.

The Chemical Profile and Significance

This benzocarbazole derivative, with its specific structural features including an ethyl group, an iodine atom, and a nitrile moiety, is not merely a chemical reagent; it's a precisely engineered molecule designed for specific synthetic pathways. Its molecular formula, C21H17IN2O, and a molecular weight of approximately 440.28 g/mol, underscore its complexity. Typically presented as a white powder, its 98% purity rating is a testament to the advanced manufacturing processes employed by specialized chemical producers. The importance of this compound is highlighted by its primary application as a precursor in the synthesis of Alectinib, a next-generation anaplastic lymphoma kinase (ALK) inhibitor. Alectinib is a targeted therapy that has shown remarkable efficacy in treating specific types of non-small cell lung cancer (NSCLC), making intermediates like CAS 1256584-80-1 indispensable for its production.

Strategic Sourcing for R&D and Production

For pharmaceutical companies and research institutions, securing a consistent and reliable supply of high-quality 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile is a strategic imperative. Procurement managers often look to manufacturers in regions like China, where specialized chemical production is concentrated, offering both scale and cost advantages. When searching for a supplier, it’s essential to look for those who demonstrate:

  • Commitment to Quality: Verified purity levels and comprehensive Certificates of Analysis (CoA).
  • Scalability: The ability to supply quantities ranging from laboratory scale for R&D to bulk volumes for commercial manufacturing.
  • Reliability: Consistent delivery schedules and transparent communication regarding stock availability and lead times.
  • Competitive Pricing: Favorable pricing structures, especially for bulk purchases, making it feasible to buy for large-scale operations.

Engaging with a manufacturer that offers flexible payment terms (L/C, T/T, PayPal) and clearly defined Incoterms (FOB, CIF) further streamlines the procurement process. For those seeking to buy this critical pharmaceutical intermediate, partnering with experienced manufacturers ensures that their drug synthesis projects are supported by a stable and high-quality supply chain.

Driving Innovation in Targeted Therapies

The continuous advancements in targeted therapy development underscore the growing importance of specialized chemical intermediates. By providing researchers and manufacturers with access to compounds like 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, the chemical industry plays a pivotal role in accelerating drug discovery and ensuring that life-saving treatments reach patients more effectively. For companies engaged in the research and production of ALK inhibitors and similar targeted agents, identifying and partnering with a proficient manufacturer and supplier of this intermediate is a key step towards achieving their therapeutic goals.