The Chemical Journey of Acetanilide (CAS 103-84-4): From Antifebrin to Industrial Staple
Acetanilide, catalogued under CAS number 103-84-4, has a fascinating trajectory in the chemical landscape. Initially recognized for its therapeutic potential as Antifebrin, it has since transitioned to become a fundamental intermediate in various industrial chemical syntheses. This transformation highlights the dynamic nature of chemical applications and the continuous search for safer, more efficient compounds.
The story of acetanilide begins in the late 19th century when it was introduced as a groundbreaking antipyretic and analgesic agent. Marketed as Antifebrin, it offered relief from fever and pain, a significant advancement in medicine at the time. However, its promising start was overshadowed by severe toxicity issues. Concerns regarding methemoglobinemia, hemolytic anemia, and damage to vital organs like the liver and kidneys led to its eventual replacement by safer alternatives, such as paracetamol, which was discovered to be its primary active metabolite in the body. This medical history serves as a crucial reminder of the importance of rigorous safety testing in drug development.
Despite its withdrawal from the pharmaceutical market, the chemical versatility of acetanilide ensured its continued relevance. Today, it is widely utilized as a key intermediate in the synthesis of a diverse array of fine chemicals. Its role in the production of pharmaceuticals remains vital, serving as a precursor for sulfa drugs and contributing to the synthesis of penicillin. The dye industry also relies heavily on acetanilide for creating various colorants, impacting everything from textiles to printing inks.
Furthermore, acetanilide finds application in the rubber industry as an accelerator, enhancing the vulcanization process, and in the stabilization of cellulose ester varnishes. Its chemical structure, N-Phenylacetamide, provides a reactive platform for further chemical transformations, making it a valuable building block for complex organic molecules.
As a leading manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality acetanilide (CAS 103-84-4) to meet the evolving demands of industrial chemistry. Whether you are interested in its historical context or its current applications in dye synthesis or as a pharmaceutical intermediate, understanding the journey of acetanilide offers valuable insights into the progression of chemical science and industry.
The story of acetanilide begins in the late 19th century when it was introduced as a groundbreaking antipyretic and analgesic agent. Marketed as Antifebrin, it offered relief from fever and pain, a significant advancement in medicine at the time. However, its promising start was overshadowed by severe toxicity issues. Concerns regarding methemoglobinemia, hemolytic anemia, and damage to vital organs like the liver and kidneys led to its eventual replacement by safer alternatives, such as paracetamol, which was discovered to be its primary active metabolite in the body. This medical history serves as a crucial reminder of the importance of rigorous safety testing in drug development.
Despite its withdrawal from the pharmaceutical market, the chemical versatility of acetanilide ensured its continued relevance. Today, it is widely utilized as a key intermediate in the synthesis of a diverse array of fine chemicals. Its role in the production of pharmaceuticals remains vital, serving as a precursor for sulfa drugs and contributing to the synthesis of penicillin. The dye industry also relies heavily on acetanilide for creating various colorants, impacting everything from textiles to printing inks.
Furthermore, acetanilide finds application in the rubber industry as an accelerator, enhancing the vulcanization process, and in the stabilization of cellulose ester varnishes. Its chemical structure, N-Phenylacetamide, provides a reactive platform for further chemical transformations, making it a valuable building block for complex organic molecules.
As a leading manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality acetanilide (CAS 103-84-4) to meet the evolving demands of industrial chemistry. Whether you are interested in its historical context or its current applications in dye synthesis or as a pharmaceutical intermediate, understanding the journey of acetanilide offers valuable insights into the progression of chemical science and industry.
Perspectives & Insights
Future Origin 2025
“The story of acetanilide begins in the late 19th century when it was introduced as a groundbreaking antipyretic and analgesic agent.”
Core Analyst 01
“Marketed as Antifebrin, it offered relief from fever and pain, a significant advancement in medicine at the time.”
Silicon Seeker One
“Concerns regarding methemoglobinemia, hemolytic anemia, and damage to vital organs like the liver and kidneys led to its eventual replacement by safer alternatives, such as paracetamol, which was discovered to be its primary active metabolite in the body.”