The Chemical Precision of 2-Butyl-3-(4-hydroxybenzoyl)benzofuran in Cardiovascular Drug Synthesis
The development of advanced pharmaceutical drugs often hinges on the precise chemical structure and purity of intermediate compounds. 2-Butyl-3-(4-hydroxybenzoyl)benzofuran (CAS 52490-15-0) exemplifies this principle, serving as a pivotal building block in the synthesis of Amiodarone hydrochloride, a vital medication for cardiovascular health. This article delves into the chemical intricacies of this compound and its indispensable role in creating life-saving treatments.
2-Butyl-3-(4-hydroxybenzoyl)benzofuran is characterized by its distinct molecular structure, featuring a benzofuran core substituted with a butyl group and a 4-hydroxybenzoyl moiety. Its physical form is typically an off-white crystalline powder, with a purity assay of ≥99.0%. The compound exhibits specific physical properties such as a melting point of 119°C and a high boiling point, contributing to its stability during complex chemical reactions. These precisely defined characteristics are not accidental; they are engineered to facilitate specific chemical transformations necessary for the synthesis of Amiodarone.
The primary application of 2-Butyl-3-(4-hydroxybenzoyl)benzofuran is in the production of Amiodarone hydrochloride. Amiodarone is a critical anti-arrhythmic drug used to treat a range of serious heart rhythm disorders, including ventricular tachycardia and atrial fibrillation. These conditions can significantly impair cardiac function and pose a threat to life. The synthetic pathway for Amiodarone relies on the specific functional groups and the overall molecular architecture of 2-Butyl-3-(4-hydroxybenzoyl)benzofuran to enable efficient conversion into the final active pharmaceutical ingredient (API). The hydroxyl group and the carbonyl group on the benzoyl ring are particularly important sites for further chemical modifications.
The precision required in synthesizing such intermediates highlights the expertise of chemical manufacturers, particularly those in China who have mastered these complex processes. Companies like NINGBO INNO PHARMCHEM CO.,LTD. ensure that each batch of 2-Butyl-3-(4-hydroxybenzoyl)benzofuran meets rigorous quality standards, guaranteeing the integrity of the downstream pharmaceutical products. This meticulous approach to chemical synthesis is fundamental to patient safety and therapeutic efficacy.
Furthermore, the study of compounds like 2-Butyl-3-(4-hydroxybenzoyl)benzofuran contributes to the broader field of medicinal chemistry. Researchers can explore its reactivity and structural nuances to develop improved synthetic routes or even discover novel applications for related benzofuran derivatives. The reliable supply of this intermediate empowers ongoing research and development efforts aimed at advancing cardiovascular care and other therapeutic areas. Ultimately, the chemical precision of this compound directly translates into improved patient outcomes.
2-Butyl-3-(4-hydroxybenzoyl)benzofuran is characterized by its distinct molecular structure, featuring a benzofuran core substituted with a butyl group and a 4-hydroxybenzoyl moiety. Its physical form is typically an off-white crystalline powder, with a purity assay of ≥99.0%. The compound exhibits specific physical properties such as a melting point of 119°C and a high boiling point, contributing to its stability during complex chemical reactions. These precisely defined characteristics are not accidental; they are engineered to facilitate specific chemical transformations necessary for the synthesis of Amiodarone.
The primary application of 2-Butyl-3-(4-hydroxybenzoyl)benzofuran is in the production of Amiodarone hydrochloride. Amiodarone is a critical anti-arrhythmic drug used to treat a range of serious heart rhythm disorders, including ventricular tachycardia and atrial fibrillation. These conditions can significantly impair cardiac function and pose a threat to life. The synthetic pathway for Amiodarone relies on the specific functional groups and the overall molecular architecture of 2-Butyl-3-(4-hydroxybenzoyl)benzofuran to enable efficient conversion into the final active pharmaceutical ingredient (API). The hydroxyl group and the carbonyl group on the benzoyl ring are particularly important sites for further chemical modifications.
The precision required in synthesizing such intermediates highlights the expertise of chemical manufacturers, particularly those in China who have mastered these complex processes. Companies like NINGBO INNO PHARMCHEM CO.,LTD. ensure that each batch of 2-Butyl-3-(4-hydroxybenzoyl)benzofuran meets rigorous quality standards, guaranteeing the integrity of the downstream pharmaceutical products. This meticulous approach to chemical synthesis is fundamental to patient safety and therapeutic efficacy.
Furthermore, the study of compounds like 2-Butyl-3-(4-hydroxybenzoyl)benzofuran contributes to the broader field of medicinal chemistry. Researchers can explore its reactivity and structural nuances to develop improved synthetic routes or even discover novel applications for related benzofuran derivatives. The reliable supply of this intermediate empowers ongoing research and development efforts aimed at advancing cardiovascular care and other therapeutic areas. Ultimately, the chemical precision of this compound directly translates into improved patient outcomes.
Perspectives & Insights
Silicon Analyst 88
“2-Butyl-3-(4-hydroxybenzoyl)benzofuran (CAS 52490-15-0) exemplifies this principle, serving as a pivotal building block in the synthesis of Amiodarone hydrochloride, a vital medication for cardiovascular health.”
Quantum Seeker Pro
“This article delves into the chemical intricacies of this compound and its indispensable role in creating life-saving treatments.”
Bio Reader 7
“2-Butyl-3-(4-hydroxybenzoyl)benzofuran is characterized by its distinct molecular structure, featuring a benzofuran core substituted with a butyl group and a 4-hydroxybenzoyl moiety.”