In the intricate world of pharmaceutical manufacturing, the selection of high-quality intermediates is paramount to ensuring the efficacy and safety of final drug products. One such critical compound is 2-Butyl-3-(4-hydroxybenzoyl)benzofuran (CAS 52490-15-0), a specialized chemical that plays an indispensable role in the synthesis of Amiodarone hydrochloride. This article delves into the properties and applications of this vital pharmaceutical intermediate, highlighting why sourcing it from a reliable supplier is crucial for drug development.

2-Butyl-3-(4-hydroxybenzoyl)benzofuran, often referred to as Amiodarone Related Compound E, is characterized by its off-white crystalline solid appearance. Its chemical profile includes a molecular formula of C19H18O3 and a molecular weight of approximately 294.34 g/mol. A key specification is its high purity, typically exceeding 99.0%, which is a non-negotiable requirement in pharmaceutical synthesis. Furthermore, its impressive thermal stability, with a boiling point of 490.6°C at 760mmHg, ensures it can withstand rigorous manufacturing processes.

The primary application of 2-Butyl-3-(4-hydroxybenzoyl)benzofuran lies in its function as a precursor for Amiodarone hydrochloride. Amiodarone is a potent anti-arrhythmic medication widely prescribed to treat serious heart conditions such as ventricular tachycardia, ventricular fibrillation, and atrial fibrillation. These conditions, if left untreated, can lead to severe complications, including myocardial infarction and angina pectoris. The structural features of 2-Butyl-3-(4-hydroxybenzoyl)benzofuran make it an ideal building block, allowing for the necessary chemical modifications to yield the final active pharmaceutical ingredient (API). By providing this crucial intermediate, manufacturers directly contribute to the availability of life-saving cardiovascular treatments.

The reliability of the supply chain for such critical intermediates is essential for pharmaceutical companies. Sourcing from reputable manufacturers in China, known for their expertise in fine chemical production, ensures consistent quality and timely delivery. This not only guarantees the integrity of the final drug product but also prevents potential disruptions in the supply of essential medicines. The demand for high-purity pharmaceutical intermediates like 2-Butyl-3-(4-hydroxybenzoyl)benzofuran underscores the importance of stringent quality control measures throughout the manufacturing process.

Beyond its direct role in Amiodarone synthesis, the compound's characteristics make it valuable in chemical research and development. Its unique benzofuran core and functional groups offer opportunities for exploring novel synthetic pathways and developing new therapeutic agents. For professionals in the pharmaceutical industry, understanding the significance of such intermediates is key to driving innovation and ensuring patient well-being. By choosing NINGBO INNO PHARMCHEM CO.,LTD. as your supplier, you secure a partner dedicated to providing the highest quality pharmaceutical intermediates to meet your demanding production needs.