For professionals in chemical synthesis and pharmaceutical research, a thorough understanding of a compound's chemical profile is essential for successful application and procurement. The 1,2,4-Thiadiazole-3-acetic acid derivative, identified by CAS 76028-96-1, is a molecule of significant interest due to its role as a critical intermediate in the synthesis of important pharmaceuticals, most notably ceftolozane. Exploring its chemical identity and properties can help potential buyers and researchers make informed decisions.

Understanding the Molecular Identity

The full chemical name of this compound is 1,2,4-Thiadiazole-3-acetic acid, 5-amino-a-[[2-(1,1-dimethylethoxy)-1,1-dimethyl-2-oxoethoxy]imino]-, (Z)-. Its CAS Registry Number, 76028-96-1, serves as a unique identifier in chemical databases worldwide. The molecular formula is C12H18N4O5S, with a molecular weight of approximately 330.36 g/mol. The presence of the Z-isomer configuration is often a critical specification for its intended use in pharmaceutical synthesis.

Key Chemical and Physical Properties

Information gathered from chemical databases and supplier specifications typically highlights several key properties:

  • Appearance: Commonly described as a white to off-white powder.
  • Purity: Typically supplied with a purity of 97% or higher, crucial for pharmaceutical applications.
  • Solubility: Generally shows slight solubility in common organic solvents like DMSO and Methanol.
  • Storage Conditions: Recommended storage is in a sealed, dry environment, often at 2-8°C, to maintain stability.
  • Predicted Properties: Data may include predicted boiling points (e.g., 487.8±47.0 °C) and densities (e.g., 1.41±0.1 g/cm³), although these are theoretical values.

The structure features a 1,2,4-thiadiazole ring, an amino group, and an imino ether side chain with tert-butoxycarbonyl protection. This intricate structure is what makes it a valuable building block for complex drug molecules.

Applications in Pharmaceutical Synthesis

The primary documented use for CAS 76028-96-1 is as a key intermediate in the preparation of ceftolozane. This antibiotic requires precise molecular architecture, making the purity and isomeric form of this precursor critical for successful synthesis and the efficacy of the final drug. Researchers may also explore its use in other organic synthesis pathways, leveraging its heterocyclic core and functional groups.

Where to Procure High-Quality Material

For those looking to buy this specialized chemical, identifying a reputable manufacturer and supplier is key. Searching for “CAS 76028-96-1 manufacturer,” “buy 1,2,4-Thiadiazole-3-acetic acid derivative,” or “pharmaceutical intermediate supplier China” will yield potential partners. We, as a dedicated manufacturer, offer this compound with guaranteed purity and stability, ensuring it meets the stringent requirements of pharmaceutical research and production. Contact us to obtain a quote and detailed specifications.