In the expansive landscape of chemical intermediates, certain compounds stand out due to their multifaceted utility and reactivity. 2-Bromo-3-methylthiophene (CAS: 14282-76-9) is one such molecule, bridging the gap between fundamental organic chemistry and critical industrial applications, from pharmaceuticals to advanced materials.

Understanding the Chemical Identity

2-Bromo-3-methylthiophene is a halogenated heterocyclic compound. Its core structure is a thiophene ring, a five-membered aromatic ring containing sulfur. Key features include:

  • Molecular Formula: C₅H₅BrS
  • Molecular Weight: Approximately 177.06 g/mol
  • CAS Number: 14282-76-9, a unique identifier crucial for global trade and regulatory purposes.
  • Physical Appearance: Typically a light yellow to clear transparent liquid, with a density around 1.6 g/cm³ and a boiling point of approximately 177°C.
  • Purity: High purity, often specified as ≥99.0%, is essential for its intended applications.

Synthesis and Reactivity

The synthesis of 2-Bromo-3-methylthiophene commonly involves the bromination of 3-methylthiophene using N-bromosuccinimide (NBS) under specific reaction conditions. The bromine atom at the 2-position is highly activated for nucleophilic substitution and cross-coupling reactions, making it an invaluable intermediate.

Its reactivity profile makes it suitable for:

  • Cross-Coupling Reactions: Facilitates the formation of carbon-carbon bonds, enabling the construction of complex organic molecules. This is crucial for creating APIs and advanced materials.
  • Functionalization: The bromine can be readily replaced by other functional groups, allowing for diverse chemical modifications.

Industrial Applications

The versatility of 2-Bromo-3-methylthiophene is evident in its broad range of industrial applications:

  • Pharmaceutical Industry: A vital intermediate in the synthesis of various drugs, most notably Tiagabine hydrochloride, an antiepileptic medication.
  • Material Science: Used in the development of conductive polymers and organic electronic materials, contributing to innovations in displays, sensors, and flexible electronics.
  • Agrochemicals: Serves as a building block for new pesticides and crop protection agents.
  • Research and Development: A standard reagent in academic and industrial labs for exploring novel chemical entities and reactions.

Sourcing and Procurement Guidance

For businesses looking to buy 2-Bromo-3-methylthiophene, identifying a reliable manufacturer is key. Companies often seek suppliers in China due to the competitive pricing and production capacity available. When sourcing, prioritize suppliers who provide:

  • High Purity: Assurance of ≥99.0% purity through Certificates of Analysis (CoA).
  • Consistent Supply: Stable production and delivery schedules.
  • Technical Support: Access to Safety Data Sheets (SDS) and product specifications.

Conclusion

2-Bromo-3-methylthiophene (CAS: 14282-76-9) exemplifies a crucial chemical intermediate that supports innovation across multiple sectors. Its robust chemical profile and diverse applications underscore its importance in modern chemical synthesis. By partnering with a reputable supplier, organizations can ensure access to this essential compound, driving progress in their respective fields.