The pharmaceutical industry constantly seeks reliable sources for critical intermediates to ensure the efficient and high-quality production of life-saving medications. For manufacturers of Dapagliflozin, an important SGLT2 inhibitor used to manage type 2 diabetes, securing a consistent supply of 2,3,4,6-Tetra-O-acetyl-D-gluconolactone (CAS 61259-48-1) is paramount. This article aims to guide procurement professionals and R&D scientists on sourcing this vital chemical intermediate.

The Crucial Role of Acetylated Gluconolactone in Dapagliflozin Production

Dapagliflozin, like Empagliflozin, belongs to the SGLT2 inhibitor class, which has revolutionized diabetes management. The synthesis of Dapagliflozin is a complex process where 2,3,4,6-Tetra-O-acetyl-D-gluconolactone serves as a key starting material or intermediate. The acetylated gluconolactone moiety provides the necessary chiral framework and functional groups that are transformed through a series of reactions to yield the final active pharmaceutical ingredient. The stereochemical integrity and purity of this intermediate are critical, as they directly impact the efficacy and safety profile of the synthesized Dapagliflozin.

Essential Purchasing Considerations:

  • Chemical Purity: For pharmaceutical applications, sourcing 2,3,4,6-Tetra-O-acetyl-D-gluconolactone with a purity of 95.0% or higher is standard practice. This ensures that the synthetic process is clean and that final product impurities are minimized.
  • Supplier Qualifications: When you choose to buy this intermediate, it’s important to select a manufacturer with a proven track record in producing high-quality pharmaceutical chemicals. Companies that provide detailed specifications, Certificates of Analysis (CoA), and adhere to stringent quality control protocols are preferred.
  • Production Scale: Ensure your chosen supplier can meet your required quantities, whether for pilot studies, clinical trials, or large-scale commercial manufacturing. Manufacturers in China often provide cost-effective solutions for bulk orders.
  • Technical Support: A supplier offering technical assistance can be invaluable for navigating synthesis challenges and optimizing reaction conditions.

Finding a Reliable Manufacturer in China

China has emerged as a global hub for chemical manufacturing, offering competitive pricing and extensive production capabilities. For those looking to buy 2,3,4,6-Tetra-O-acetyl-D-gluconolactone, partnering with a reputable Chinese chemical company can be a strategic advantage. We pride ourselves on being a trusted supplier of pharmaceutical intermediates, dedicated to providing high-purity chemicals that meet international standards. Our commitment to quality and customer service ensures that your procurement process is smooth and reliable.

We invite pharmaceutical companies to inquire about our 2,3,4,6-Tetra-O-acetyl-D-gluconolactone. Contact us today for a quotation and to discuss how we can support your Dapagliflozin synthesis needs.