In the pharmaceutical industry, the precise understanding and reliable sourcing of chemical intermediates are fundamental to successful API production. 4-Hydroxybenzaldehyde, identified by its CAS number 123-08-0, is a compound of significant importance, primarily serving as a crucial intermediate in the synthesis of Ezetimibe, a widely recognized cholesterol-lowering drug. This article provides a detailed look at the chemical profile of 4-Hydroxybenzaldehyde and highlights why its quality and consistent availability are non-negotiable for pharmaceutical manufacturers. For those looking to buy this essential component, partnering with a reputable manufacturer offering high-purity material is key.

Chemical Properties and Specifications of 4-Hydroxybenzaldehyde

4-Hydroxybenzaldehyde (also known as p-Hydroxybenzaldehyde) is an aromatic aldehyde with the molecular formula C7H6O2. Its structure features a benzene ring substituted with both an aldehyde group (-CHO) and a hydroxyl group (-OH). These functional groups impart its reactivity and make it a valuable building block in organic synthesis.

Key physical and chemical properties relevant to its use in pharmaceutical manufacturing include:

  • Appearance: Typically a white to light yellow crystalline powder.
  • Assay (Purity): High purity is critical, with pharmaceutical-grade material usually requiring ≥99.5%.
  • Melting Point: The range of 112-116 °C indicates the compound's purity and crystalline structure.
  • Molecular Weight: 122.12 g/mol.
  • Boiling Point: Approximately 246.6 °C at 760 mmHg.
  • Flash Point: Around 101.3 °C, important for safety considerations during handling and processing.
  • Solubility: Soluble in organic solvents like ethanol and ether, less soluble in water.

These properties are essential for R&D scientists and process engineers to design and optimize synthetic routes. A supplier that provides detailed technical data sheets is invaluable.

The Critical Link to Ezetimibe Production

The efficacy of Ezetimibe relies heavily on the stereochemical integrity and purity achieved during its multi-step synthesis. 4-Hydroxybenzaldehyde plays a pivotal role in establishing specific parts of the Ezetimibe molecule. Utilizing a high-purity intermediate directly contributes to:

  • Improved reaction yields and efficiency.
  • Minimized formation of impurities, simplifying downstream purification.
  • Consistent batch-to-batch quality of the final API.
  • Cost-effectiveness by reducing rework or material rejection.

For API manufacturers, sourcing this intermediate from a reliable manufacturer in China ensures access to quality materials at competitive prices, supporting both operational efficiency and cost management.

Choosing Your Supplier Wisely

When you decide to purchase 4-Hydroxybenzaldehyde, prioritize suppliers who offer not just the product but also a partnership built on quality assurance, consistent supply, and technical support. We are committed to being that partner, providing pharmaceutical manufacturers with the high-quality 4-Hydroxybenzaldehyde (CAS 123-08-0) necessary for successful Ezetimibe synthesis.