Monomethyl Fumarate, identified by the CAS number 2756-87-8 and also known as Fumaric Acid Monomethyl Ester, is a compound of notable importance in the chemical synthesis sector, especially within the pharmaceutical industry. Its primary utility is as a pharmaceutical intermediate, a critical component in the manufacturing pathway of various complex molecules. This article aims to outline the detailed chemical profile of Monomethyl Fumarate, emphasizing its specifications and its role in advanced synthesis, including its use in producing Neratinib. Reliable sourcing of such intermediates is key for progress in drug development.

The fundamental chemical identity of Monomethyl Fumarate is defined by its formula C5H6O4 and a molecular weight of approximately 130.10. As a white crystalline powder, its physical form offers ease of handling and integration into chemical processes. A crucial parameter for its application is its melting point, reliably reported within the range of 144-145°C. This narrow melting range is a strong indicator of high purity, typically assessed by an assay of ≥98.0%. Such purity is essential for its role as a pharmaceutical intermediate, ensuring that downstream reactions are efficient and that the final product, such as Neratinib, meets stringent quality and safety standards without unwanted byproducts.

The significance of Monomethyl Fumarate is most prominently recognized in its application as a precursor for Neratinib (CAS: 698387-09-6). Neratinib is a vital drug used in the treatment of specific types of breast cancer, highlighting the critical nature of its synthesis. The consistent availability of high-quality Monomethyl Fumarate is thus paramount for pharmaceutical manufacturers aiming to produce this life-saving medication. As a key component in the synthesis of complex APIs, this compound exemplifies the intricate supply chain requirements of modern drug production. Procuring materials with guaranteed specifications, often from a leading supplier in China, ensures the reliability and scalability of these processes.

In organic synthesis beyond pharmaceuticals, Monomethyl Fumarate serves as a valuable building block. Its reactivity and structural features make it suitable for various chemical transformations, contributing to the broader field of fine chemical synthesis. For research institutions and chemical development companies, having access to precisely characterized intermediates like CAS 2756-87-8 is fundamental for innovation. The detailed chemical profile provided by reliable sources empowers chemists to design and execute complex synthetic strategies with greater confidence, accelerating the development of new compounds and technologies.

In conclusion, Monomethyl Fumarate is a crucial compound with a well-defined chemical profile that supports critical synthesis applications, particularly in the pharmaceutical sector for Neratinib production. Its purity, physical form, and specific chemical properties underscore its value as an indispensable pharmaceutical intermediate. For organizations requiring this compound, partnering with dependable suppliers who provide comprehensive documentation and consistent quality is essential for achieving successful synthesis outcomes.