Monomethyl Fumarate, identified by its CAS number 2756-87-8, is a chemical compound of significant interest within the pharmaceutical and fine chemical industries. Known also by synonyms such as Fumaric Acid Monomethyl Ester or Monomethyl fumarate, it serves a pivotal role as a pharmaceutical intermediate. This article aims to detail its specific chemical and physical specifications, underscoring its importance in synthesis processes, particularly for advanced therapeutic compounds like Neratinib. Understanding these details is essential for chemists and procurement specialists seeking high-quality materials for their projects.

The compound's physical presentation is a white crystalline powder, a standard form for many high-purity organic chemicals. This morphology is indicative of its processed nature and helps in its handling and integration into chemical reactions. The molecular formula of Monomethyl Fumarate is C5H6O4, with a calculated molecular weight of 130.10 g/mol. These basic identifiers are fundamental for any chemical synthesis. Crucially, its melting point is precisely documented as 144-145°C. This narrow range for melting is a strong indicator of high purity, a non-negotiable attribute for pharmaceutical intermediate applications. A high assay, typically ≥98.0%, further confirms its suitability for demanding synthesis protocols, minimizing unwanted side reactions or impurities in the final product.

The primary application driving the demand for Monomethyl Fumarate is its function as a precursor in the synthesis of Neratinib. Neratinib is a targeted therapy agent used in the treatment of specific forms of breast cancer, making the quality of its intermediates paramount. The chemical structure of Monomethyl Fumarate is designed to be readily incorporated into the complex molecular architecture of Neratinib, facilitating efficient and high-yield synthesis. The reliability of this pharmaceutical intermediate is crucial for the consistent production of essential cancer medications.

Sourcing chemicals like Monomethyl Fumarate requires careful consideration of the supplier's capabilities and quality assurance processes. Companies often rely on established manufacturers, including those operating as a prominent supplier in China, to secure consistent supplies of CAS 2756-87-8. These suppliers provide detailed certificates of analysis that confirm the material meets specified purity and physical property standards. This due diligence in sourcing is a cornerstone of good manufacturing practices (GMP) in the pharmaceutical sector.

In summary, Monomethyl Fumarate is a key chemical intermediate characterized by its high purity, crystalline powder form, and specific melting point. Its vital role in the synthesis of Neratinib and its utility in broader organic chemistry applications highlight its importance in the pharmaceutical industry. For researchers and manufacturers, understanding and sourcing Monomethyl Fumarate with high specifications is essential for successful and compliant chemical synthesis, ensuring the quality of the final therapeutic products.