In the intricate world of organic chemistry and pharmaceutical development, understanding the precise chemical profile of intermediates is fundamental to successful synthesis and product innovation. One such crucial compound is (S)-1-tosyl-3-(1-cyano-1,1-diphenylmethyl)pyrrolidine, identified by its CAS number 133099-09-9. This chiral molecule is a highly valued building block, particularly recognized for its role in the synthesis of important pharmaceuticals.

The chemical name itself, (S)-1-tosyl-3-(1-cyano-1,1-diphenylmethyl)pyrrolidine, hints at its complex structure. It features a pyrrolidine ring, a five-membered nitrogen-containing heterocycle, which is a common structural motif in many biologically active molecules. Attached to the nitrogen atom is a tosyl group (p-toluenesulfonyl), which often serves to modify the electronic properties or act as a leaving group in synthesis. The pyrrolidine ring is further substituted at the 3-position with a carbon atom bearing a cyano group (-CN) and two phenyl rings, forming a diphenylmethyl moiety. The crucial aspect is the defined stereochemistry at the 3-position, indicated by the (S) designation, which is vital for its intended applications in chiral synthesis.

Physically, this compound is described as a white crystalline powder. This solid form, combined with its molecular formula C25H24N2O2S and molecular weight of 416.54 g/mol, provides chemists with essential data for handling and reaction planning. Its solubility characteristics, often in organic solvents like chloroform or ethyl acetate, are also important considerations for process chemists when designing synthetic routes. When you purchase CAS 133099-09-9 from a reputable supplier, this detailed information is readily available, typically via a Certificate of Analysis (CoA).

The primary application of (S)-1-tosyl-3-(1-cyano-1,1-diphenylmethyl)pyrrolidine lies in its use as a key intermediate in the synthesis of Darifenacin and its hydrobromide salt. Darifenacin is a muscarinic receptor antagonist, primarily used to treat symptoms of an overactive bladder. The precise chiral nature of the intermediate is critical to achieving the desired pharmacological activity of the final drug product. Therefore, sourcing this compound from a reliable pharmaceutical intermediate manufacturer that guarantees high enantiomeric purity is non-negotiable for drug developers and manufacturers.

Beyond its pharmaceutical applications, the unique combination of functional groups and the chiral center makes this molecule an interesting subject for broader organic synthesis research. Scientists exploring new synthetic methodologies or designing novel chiral compounds may find this intermediate a valuable starting material. As a leading supplier of fine chemicals, we offer this critical building block to researchers and manufacturers alike, ensuring quality and availability. If you are looking to buy (S)-1-tosyl-3-(1-cyano-1,1-diphenylmethyl)pyrrolidine, consider our commitment to providing high-purity intermediates for your most demanding projects.