The world of organic chemistry is built upon a foundation of precise molecular structures and reactive intermediates. 4-Fluorocinnamic Acid, with its CAS number 459-32-5, is one such compound that holds significant importance, especially within the pharmaceutical and fine chemical industries. Understanding its intrinsic properties is key for chemists and procurement specialists looking to leverage its potential. As a dedicated supplier, we aim to illuminate these aspects and guide you on sourcing this valuable chemical.

Chemical Identity and Characteristics

4-Fluorocinnamic Acid is classified as a fluorinated derivative of cinnamic acid. Its chemical formula is C9H7FO2, and it has a molecular weight of 166.15. The compound's structure features a phenyl ring with a fluorine atom at the para position, attached to a propenoic acid moiety. Physically, it is typically presented as a white to light yellow crystalline powder. Its melting point is a critical characteristic, recorded in the range of 209-210°C, indicating a relatively stable solid form under ambient conditions. The pKa value, predicted around 4.43, suggests it is a weak organic acid, readily participating in acid-base reactions.

Reactivity and Functional Groups

The versatility of 4-Fluorocinnamic Acid in chemical synthesis arises from its distinct functional groups. The carboxylic acid group (-COOH) allows for typical reactions such as esterification, amidation, and salt formation. The alpha, beta-unsaturated carboxylic acid system, specifically the trans double bond, is susceptible to addition reactions, including hydrogenation, epoxidation, and Michael additions. The phenyl ring, activated by the electron-withdrawing fluorine atom, can also undergo electrophilic aromatic substitution under specific conditions, although the fluorine itself is generally stable. This rich reactivity profile makes it an excellent intermediate for constructing more complex organic molecules, particularly those intended for pharmaceutical or agrochemical applications.

Applications and Synthesis Potential

As a pharmaceutical intermediate, 4-Fluorocinnamic Acid is instrumental in synthesizing various APIs. The introduction of a fluorine atom can significantly impact a drug's metabolic stability, lipophilicity, and binding interactions, making it a desirable feature in drug design. Its use in organic synthesis extends to the creation of specialty polymers, dyes, and other fine chemicals. For researchers and manufacturers looking to buy this compound, ensuring high purity (e.g., 98% or higher) and consistent quality from a reliable supplier is paramount. Manufacturers in China are known for their production capabilities and competitive pricing, making them accessible sources for this essential chemical.

Sourcing Recommendations

When procuring 4-Fluorocinnamic Acid (CAS 459-32-5), it is recommended to work with established manufacturers and suppliers. Key considerations include:

  • Purity: Aim for ≥98% purity, or higher if your application demands it.
  • Supplier Reputation: Choose vendors with strong quality control and positive feedback.
  • Pricing and Availability: Compare quotes and confirm consistent supply capabilities.
  • Technical Data: Ensure access to Safety Data Sheets (SDS) and Certificates of Analysis (CoA).

By understanding the chemical properties and engaging with reputable sources, buyers can effectively utilize 4-Fluorocinnamic Acid in their research and production. We invite you to request a quote for 4-Fluorocinnamic Acid to experience our commitment to quality and service.