For chemists and researchers engaged in pharmaceutical synthesis and organic chemistry, a thorough understanding of the chemical and physical properties of key intermediates is indispensable. 4-Hydroxypyrrolo[2,3-d]pyrimidine, identified by CAS number 3680-71-5, is one such compound whose characteristics dictate its utility and handling in various laboratory and industrial settings.

This heterocyclic compound, with the molecular formula C6H5N3O and a molecular weight of approximately 135.12 g/mol, is typically characterized by its appearance as a brown solid. This physical state is common for many complex organic intermediates and is a primary identifier upon receipt. Its structure, a fused pyrrolo and pyrimidine ring system, is the basis for its reactivity and its role as a versatile building block.

Key physicochemical data points that researchers often consider include its melting point, boiling point, and solubility. While precise figures can vary slightly between suppliers and purity levels, reported melting points for 4-Hydroxypyrrolo[2,3-d]pyrimidine are consistently high, often in the range of 345-348°C, indicating a stable crystalline structure. Predicted boiling points are also notably high, suggesting that thermal decomposition might occur before boiling at atmospheric pressure.

Solubility is another critical parameter. Information typically indicates that it is soluble in polar aprotic solvents like dimethyl sulfoxide (DMSO), a common characteristic for molecules with polar functional groups and heterocyclic nitrogen atoms. Understanding its solubility profile is crucial for designing reaction conditions and purification protocols.

Safety information is also paramount. Hazard statements such as H317 (May cause an allergic skin reaction) and H319 (Causes serious eye irritation) are often associated with this compound, alongside warnings about potential moisture and light sensitivity. Proper handling procedures, including the use of personal protective equipment (PPE) like gloves, eye protection, and appropriate ventilation, are therefore essential when working with it.

As a supplier of 4-Hydroxypyrrolo[2,3-d]pyrimidine, we ensure that detailed specifications and safety data sheets (SDS) are readily available to our clients. This commitment to transparency empowers R&D scientists and formulation chemists to confidently incorporate this vital intermediate into their synthesis pathways, whether for academic research or industrial production of pharmaceuticals.