Understanding the Chemical Properties of 6-Bromo-3-methyl-indolin-2-one for Synthesis
The utility of any chemical intermediate in organic synthesis is intrinsically linked to its chemical properties. For 6-Bromo-3-methyl-indolin-2-one (CAS 90725-50-1), understanding these characteristics is paramount for chemists aiming to leverage it effectively in the creation of complex molecules, particularly within the pharmaceutical sector.
6-Bromo-3-methyl-indolin-2-one, as its name suggests, is an indole derivative. The indole nucleus is a ubiquitous scaffold in natural products and pharmaceuticals, known for its diverse biological activities. The specific substitutions on this molecule – a bromine atom at the 6-position and a methyl group at the 3-position, along with the oxo group at the 2-position of the indoline ring – impart distinct chemical behaviors.
The bromine atom, being an electron-withdrawing group and a good leaving group, makes the aromatic ring susceptible to nucleophilic aromatic substitution reactions under specific conditions. It also serves as a handle for palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings, which are indispensable tools for building carbon-carbon bonds and creating more complex molecular architectures. These reactions are fundamental in the synthesis of many API precursors.
The methyl group at the 3-position can influence the steric and electronic environment around the indole core, potentially affecting regioselectivity and reaction rates in subsequent transformations. The lactam (cyclic amide) functionality within the indolin-2-one structure also offers sites for chemical modification, such as reduction or reaction at the alpha-carbon to the carbonyl group.
For R&D scientists and procurement managers seeking to buy 6-Bromo-3-methyl-indolin-2-one, having access to detailed information about its reactivity, solubility, and stability is crucial. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. provide this essential data, often including CAS number (90725-50-1), molecular formula (C9H8BrNO), and molecular weight (226.07 g/mol). The physical appearance is typically described as a solid, which is common for such organic compounds.
When sourcing this intermediate, remember that its precise chemical properties dictate its suitability for specific synthetic routes. Therefore, engaging with knowledgeable suppliers who can offer technical insights into the compound’s behavior is highly beneficial. Ultimately, a thorough understanding of the chemical properties of 6-Bromo-3-methyl-indolin-2-one empowers chemists to unlock its full potential in synthesizing innovative pharmaceutical compounds.
6-Bromo-3-methyl-indolin-2-one, as its name suggests, is an indole derivative. The indole nucleus is a ubiquitous scaffold in natural products and pharmaceuticals, known for its diverse biological activities. The specific substitutions on this molecule – a bromine atom at the 6-position and a methyl group at the 3-position, along with the oxo group at the 2-position of the indoline ring – impart distinct chemical behaviors.
The bromine atom, being an electron-withdrawing group and a good leaving group, makes the aromatic ring susceptible to nucleophilic aromatic substitution reactions under specific conditions. It also serves as a handle for palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings, which are indispensable tools for building carbon-carbon bonds and creating more complex molecular architectures. These reactions are fundamental in the synthesis of many API precursors.
The methyl group at the 3-position can influence the steric and electronic environment around the indole core, potentially affecting regioselectivity and reaction rates in subsequent transformations. The lactam (cyclic amide) functionality within the indolin-2-one structure also offers sites for chemical modification, such as reduction or reaction at the alpha-carbon to the carbonyl group.
For R&D scientists and procurement managers seeking to buy 6-Bromo-3-methyl-indolin-2-one, having access to detailed information about its reactivity, solubility, and stability is crucial. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. provide this essential data, often including CAS number (90725-50-1), molecular formula (C9H8BrNO), and molecular weight (226.07 g/mol). The physical appearance is typically described as a solid, which is common for such organic compounds.
When sourcing this intermediate, remember that its precise chemical properties dictate its suitability for specific synthetic routes. Therefore, engaging with knowledgeable suppliers who can offer technical insights into the compound’s behavior is highly beneficial. Ultimately, a thorough understanding of the chemical properties of 6-Bromo-3-methyl-indolin-2-one empowers chemists to unlock its full potential in synthesizing innovative pharmaceutical compounds.
Perspectives & Insights
Alpha Spark Labs
“The utility of any chemical intermediate in organic synthesis is intrinsically linked to its chemical properties.”
Future Pioneer 88
“For 6-Bromo-3-methyl-indolin-2-one (CAS 90725-50-1), understanding these characteristics is paramount for chemists aiming to leverage it effectively in the creation of complex molecules, particularly within the pharmaceutical sector.”
Core Explorer Pro
“The indole nucleus is a ubiquitous scaffold in natural products and pharmaceuticals, known for its diverse biological activities.”