Chemical Properties and Analytical Standards of Ethyl 2-((5-Chloropyridin-2-yl)amino)-2-oxoacetate Hydrochloride
Understanding the precise chemical properties of pharmaceutical intermediates is fundamental for their effective application in drug synthesis and quality control. Ethyl 2-((5-Chloropyridin-2-yl)amino)-2-oxoacetate Hydrochloride, bearing the CAS number 1243308-37-3, is a compound of significant interest within the pharmaceutical industry, primarily due to its role as an intermediate in the synthesis of Edoxaban, a potent anticoagulant. This white powder is characterized by its molecular formula C9H10Cl2N2O3 and a molecular weight of 265.09.
The chemical stability and reactivity of this intermediate are critical factors for chemists involved in Edoxaban production. Its precise structure, including the chloropyridine and ethyl ester moieties, dictates its behavior in various synthetic transformations. Reliable manufacturers provide detailed specifications, including solubility profiles, often noting its solubility in DMSO, which is common for many organic intermediates. These properties are essential for designing efficient reaction conditions and purification protocols.
Beyond its direct use in synthesis, Ethyl 2-((5-Chloropyridin-2-yl)amino)-2-oxoacetate Hydrochloride also serves as an important analytical standard. In the quality control (QC) of Edoxaban, reference standards are indispensable for identifying and quantifying impurities, verifying the purity of the active pharmaceutical ingredient (API), and validating analytical methods such as High-Performance Liquid Chromatography (HPLC). Pharmaceutical companies rely on these standards to ensure their products meet regulatory requirements and industry best practices. Access to well-characterized intermediates as analytical standards is a cornerstone of robust pharmaceutical quality assurance.
Suppliers like NINGBO INNO PHARMCHEM CO.,LTD. often provide these intermediates with comprehensive analytical data, including NMR, Mass Spectrometry, and HPLC chromatograms. This data ensures that the material is precisely what it claims to be, facilitating its use in sensitive analytical applications. The availability of such detailed chemical information underscores the importance of this compound not just as a synthetic building block but also as a crucial tool in maintaining the highest standards of pharmaceutical quality and safety.
The chemical stability and reactivity of this intermediate are critical factors for chemists involved in Edoxaban production. Its precise structure, including the chloropyridine and ethyl ester moieties, dictates its behavior in various synthetic transformations. Reliable manufacturers provide detailed specifications, including solubility profiles, often noting its solubility in DMSO, which is common for many organic intermediates. These properties are essential for designing efficient reaction conditions and purification protocols.
Beyond its direct use in synthesis, Ethyl 2-((5-Chloropyridin-2-yl)amino)-2-oxoacetate Hydrochloride also serves as an important analytical standard. In the quality control (QC) of Edoxaban, reference standards are indispensable for identifying and quantifying impurities, verifying the purity of the active pharmaceutical ingredient (API), and validating analytical methods such as High-Performance Liquid Chromatography (HPLC). Pharmaceutical companies rely on these standards to ensure their products meet regulatory requirements and industry best practices. Access to well-characterized intermediates as analytical standards is a cornerstone of robust pharmaceutical quality assurance.
Suppliers like NINGBO INNO PHARMCHEM CO.,LTD. often provide these intermediates with comprehensive analytical data, including NMR, Mass Spectrometry, and HPLC chromatograms. This data ensures that the material is precisely what it claims to be, facilitating its use in sensitive analytical applications. The availability of such detailed chemical information underscores the importance of this compound not just as a synthetic building block but also as a crucial tool in maintaining the highest standards of pharmaceutical quality and safety.
Perspectives & Insights
Molecule Vision 7
“Reliable manufacturers provide detailed specifications, including solubility profiles, often noting its solubility in DMSO, which is common for many organic intermediates.”
Alpha Origin 24
“These properties are essential for designing efficient reaction conditions and purification protocols.”
Future Analyst X
“Beyond its direct use in synthesis, Ethyl 2-((5-Chloropyridin-2-yl)amino)-2-oxoacetate Hydrochloride also serves as an important analytical standard.”