2-Fluoro-5-iodonitrobenzene (CAS 364-75-0) is a molecule of significant interest in the realm of fine chemicals and pharmaceutical intermediates due to its unique chemical architecture. As a valued product from leading chemical manufacturers, understanding its properties is key to unlocking its full synthetic potential. This compound offers researchers and industrial chemists a powerful tool for constructing complex organic molecules. If you are looking to buy this chemical, knowing its characteristics will guide your procurement decisions.

The molecular formula C6H3FINO2 and a molecular weight of approximately 267 g/mol define its fundamental composition. As an organic synthesis intermediate, its appearance as a solid with a defined melting point (though specific values can vary, it is generally a solid at room temperature) makes it convenient to handle and store. The presence of the nitro group (-NO2) deactivates the benzene ring towards electrophilic aromatic substitution but activates it for nucleophilic aromatic substitution, particularly at positions ortho and para to it. The fluorine atom, being highly electronegative, further influences the electron distribution and reactivity of the ring. The iodine atom is a key functional group, serving as an excellent leaving group in transition metal-catalyzed cross-coupling reactions.

One of the most exploited properties of 2-fluoro-5-iodonitrobenzene is the reactivity of the carbon-iodine bond. This bond readily participates in palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura coupling (with boronic acids), Sonogashira coupling (with terminal alkynes), and Heck reaction (with alkenes). These reactions are indispensable for forming new carbon-carbon bonds, a cornerstone of modern organic synthesis. The ability to selectively functionalize this position allows for the precise introduction of diverse organic fragments, leading to a vast array of downstream products.

Furthermore, the nitro group can be readily reduced to an amino group (-NH2), providing another avenue for functionalization and the creation of aniline derivatives. This transformation is critical in the synthesis of many biologically active compounds. The fluorine atom can also influence the pharmacokinetic properties of the final drug molecules, such as increasing metabolic stability and lipophilicity. Therefore, its role as a pharmaceutical intermediate is well-established.

For companies seeking to procure this valuable compound, sourcing from reliable suppliers in China is often the most cost-effective approach. These manufacturers are equipped with the necessary infrastructure and expertise to produce CAS 364-75-0 with high purity and consistency. When inquiring about price, it is important to consider not just the cost per kilogram but also the overall value, including purity, availability, and the supplier's reliability. Many offer free samples to qualified buyers, allowing for an initial assessment of quality.

In conclusion, the chemical properties of 2-Fluoro-5-iodonitrobenzene make it a powerhouse intermediate for various synthetic applications, particularly in the pharmaceutical and fine chemical sectors. Its reactivity at multiple sites allows for sophisticated molecular construction. By partnering with experienced manufacturers and suppliers, you can reliably access this essential building block to advance your research and production goals.