Understanding the detailed chemical and physical properties of a pharmaceutical intermediate is fundamental to its effective utilization in complex synthesis pathways. 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone (CAS 58113-30-7), supplied by NINGBO INNO PHARMCHEM CO.,LTD., is a prime example of such a critical compound, essential for the production of Iloperidone. Its specific attributes make it a sought-after chemical in the fine chemical industry.

The molecular formula C12H15ClO3 and a molecular weight of 242.699 g/mol define the basic composition of this intermediate. Its physical appearance as a white crystalline powder is a key indicator of its purity. The reported density of 1.1±0.1 g/cm³ and a high boiling point of 367.0±27.0 °C at 760 mmHg speak to its relative stability under various conditions. The flash point of 149.8±22.7 °C also provides important safety information for handling and storage.

From a chemical perspective, the assay of ≥98.0-102.0% by HPLC is a critical specification, ensuring that the material is suitable for pharmaceutical synthesis, where impurity profiles are rigorously controlled. Low loss on drying (≤0.5%) and residue on ignition (≤0.1%) further confirm the product's high quality and low impurity content, which are vital for achieving the desired yield and purity in the synthesis of Iloperidone. The presence of heavy metals is also carefully monitored, with limits set at ≤20ppm.

The primary application of 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone lies in its role as an intermediate for Iloperidone. This antipsychotic medication requires precise chemical building blocks, and this compound's unique structure facilitates the necessary reactions. The efficacy of the final drug is directly linked to the quality of its intermediates, making the meticulous control of properties like those listed above indispensable.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing comprehensive technical data and ensuring that each batch of 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone meets these exacting standards. By understanding and controlling these chemical and physical properties, we enable pharmaceutical manufacturers to achieve optimal results in their synthesis processes, ultimately contributing to the availability of effective treatments for conditions like schizophrenia.