Understanding the precise chemical properties of intermediates is fundamental for chemists and product developers to unlock their full potential. 5-Bromo-2-fluorobenzoic acid (CAS 146328-85-0) is a compound that offers a rich array of chemical characteristics, making it a valuable asset in diverse fields ranging from pharmaceuticals to advanced materials. As a leading manufacturer and supplier in China, we are dedicated to providing high-quality chemical products and essential technical information to our B2B clients. This article explores the key chemical properties and applications of 5-Bromo-2-fluorobenzoic acid.

Chemically, 5-Bromo-2-fluorobenzoic acid is an aromatic carboxylic acid characterized by the presence of a fluorine atom at the ortho position and a bromine atom at the para position relative to the carboxyl group. This specific halogenation pattern influences the molecule's acidity and reactivity. The electron-withdrawing nature of both fluorine and bromine, combined with the resonance effects within the aromatic ring, impacts the pKa of the carboxylic acid group, making it a moderately strong acid. Its melting point, typically between 141-145 °C (lit.), indicates it is a solid under ambient conditions, appearing as a white to light yellow to light orange powder or crystal. The compound exhibits slight solubility in water, a common characteristic for many organic acids, but is generally soluble in common organic solvents.

The applications of 5-Bromo-2-fluorobenzoic acid are as diverse as its chemical properties. In the pharmaceutical sector, it serves as a crucial intermediate for the synthesis of various therapeutic agents. Its structure is frequently incorporated into drug candidates targeting inflammatory conditions, neurological disorders, and certain types of cancer. The ability to participate in cross-coupling reactions allows chemists to build complex heterocyclic systems or introduce specific functionalities essential for biological activity. In agrochemistry, it plays a role in the synthesis of potent herbicides and pesticides, contributing to improved crop protection and yield. Furthermore, its unique properties make it useful in material science for the development of specialty polymers or functional coatings.

For professionals in the chemical industry, sourcing reliable intermediates is as important as understanding their chemistry. We ensure that our 5-Bromo-2-fluorobenzoic acid is manufactured to high standards, with a purity of ≥ 97% (GC), suitable for demanding applications. Our role as a manufacturer and supplier in China allows us to offer competitive pricing and consistent availability, facilitating the purchase of this compound for both research and commercial production. If you are looking to buy 5-Bromo-2-fluorobenzoic acid and require a dependable partner, we invite you to contact us. We are committed to providing the chemical building blocks that drive innovation across industries.