N-Methoxycarbonyl-L-Valine, identified by CAS number 74761-42-5, is a chemically modified amino acid that has found significant utility within the pharmaceutical and fine chemical industries. Its structure, scientifically denoted as (S)-2-((Methoxycarbonyl)amino)-3-methylbutanoic acid, underscores its role as a derivative of the naturally occurring amino acid L-valine. This article explores its key chemical properties and the diverse applications that make it a sought-after intermediate for researchers and manufacturers globally.

From a chemical perspective, MOC-L-Valine (as it is often abbreviated) possesses a molecular formula of C7H13NO4 and a molecular weight of approximately 175.18 g/mol. Its physical appearance is typically a white to off-white crystalline powder, indicating a high degree of purity and a solid form at room temperature. Key physical properties such as a melting point ranging from 109.0 to 113.0 °C and a predicted boiling point of 315.9 ± 25.0 °C at 760 mmHg contribute to its stability during synthesis and handling. The compound's solubility characteristics, often described as soluble in water but insoluble in alcohol, are also important considerations for process chemists.

The primary value of N-Methoxycarbonyl-L-Valine lies in its function as a pharmaceutical intermediate. The methoxycarbonyl protecting group on the amine function makes it an excellent choice for controlled synthetic routes. This protection prevents unwanted reactions at the amino group, allowing chemists to perform modifications elsewhere on the molecule or to couple it with other peptide fragments with high specificity. This is particularly crucial in the synthesis of complex molecules where stereochemistry and regioselectivity are paramount.

Its most prominent application is in the synthesis of antiviral drugs. Specifically, it is a key precursor for manufacturing Ledipasvir and Daclatasvir, both of which are vital components in the treatment of Hepatitis C. The demand for these life-saving medications directly translates into a consistent need for high-quality MOC-L-Valine. Pharmaceutical manufacturers rely on its purity and reliable supply chain to ensure the efficient production of these critical therapies.

Beyond these major antiviral applications, MOC-L-Valine also serves as a valuable tool in broader medicinal chemistry research. Its structure makes it suitable for creating novel peptide analogs, exploring new amino acid-based therapeutics, and developing specialized compounds for drug delivery systems. For companies looking to buy this intermediate, partnering with established manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. ensures that they receive a product meeting stringent specifications. This commitment to quality underpins successful research and development efforts, ultimately contributing to the advancement of pharmaceutical science.