Chemical Properties and Handling of Hoffer's Chlorosugar (CAS 4330-21-6)
Hoffer's chlorosugar, scientifically known as 2-Deoxy-alpha-D-erythropentofuranosyl chloride 3,5-bis(4-methylbenzoate) (CAS 4330-21-6), possesses specific chemical properties that are critical for its successful application in synthesis. As a derivative of a sugar molecule, its structure is key to its reactivity and handling requirements. Understanding these properties is essential for chemists and technicians working with this compound.
Primarily, Hoffer's chlorosugar is described as a white solid. Its melting point, typically in the range of 117-119 °C, serves as a useful indicator of its purity. Higher purity generally correlates with a sharper melting point range. The presence of the chlorine atom at the anomeric position makes this molecule a reactive electrophile, readily undergoing nucleophilic substitution reactions. This characteristic is fundamental to its use as a glycosyl donor in the formation of glycosidic bonds, a common step in the synthesis of pharmaceuticals and other complex organic molecules.
Another critical property is its stability. Hoffer's chlorosugar is noted as being moisture sensitive. Exposure to moisture can lead to hydrolysis of the anomeric chloride, reducing the compound's effectiveness and potentially forming unwanted byproducts. Therefore, it is crucial to store this chemical in tightly sealed containers, preferably under an inert atmosphere, and in a dry environment. Refrigeration, typically at -20°C, is also recommended to maintain its integrity and shelf life. Suppliers like NINGBO INNO PHARMCHEM CO.,LTD. ensure proper packaging and storage conditions to deliver the product in optimal condition.
When handling Hoffer's chlorosugar, standard laboratory safety practices should be rigorously followed. This includes wearing appropriate personal protective equipment (PPE) such as gloves, eye protection, and lab coats. Working in a well-ventilated area, such as a fume hood, is advisable to avoid inhalation of any potential dust or vapors. Given its reactivity, compatibility with other chemicals should always be considered. For any specific safety concerns or detailed handling instructions, consulting the Material Safety Data Sheet (MSDS) provided by the supplier, such as NINGBO INNO PHARMCHEM CO.,LTD., is highly recommended. By adhering to these guidelines, professionals can safely and effectively utilize this important chemical intermediate in their synthetic endeavors.
Primarily, Hoffer's chlorosugar is described as a white solid. Its melting point, typically in the range of 117-119 °C, serves as a useful indicator of its purity. Higher purity generally correlates with a sharper melting point range. The presence of the chlorine atom at the anomeric position makes this molecule a reactive electrophile, readily undergoing nucleophilic substitution reactions. This characteristic is fundamental to its use as a glycosyl donor in the formation of glycosidic bonds, a common step in the synthesis of pharmaceuticals and other complex organic molecules.
Another critical property is its stability. Hoffer's chlorosugar is noted as being moisture sensitive. Exposure to moisture can lead to hydrolysis of the anomeric chloride, reducing the compound's effectiveness and potentially forming unwanted byproducts. Therefore, it is crucial to store this chemical in tightly sealed containers, preferably under an inert atmosphere, and in a dry environment. Refrigeration, typically at -20°C, is also recommended to maintain its integrity and shelf life. Suppliers like NINGBO INNO PHARMCHEM CO.,LTD. ensure proper packaging and storage conditions to deliver the product in optimal condition.
When handling Hoffer's chlorosugar, standard laboratory safety practices should be rigorously followed. This includes wearing appropriate personal protective equipment (PPE) such as gloves, eye protection, and lab coats. Working in a well-ventilated area, such as a fume hood, is advisable to avoid inhalation of any potential dust or vapors. Given its reactivity, compatibility with other chemicals should always be considered. For any specific safety concerns or detailed handling instructions, consulting the Material Safety Data Sheet (MSDS) provided by the supplier, such as NINGBO INNO PHARMCHEM CO.,LTD., is highly recommended. By adhering to these guidelines, professionals can safely and effectively utilize this important chemical intermediate in their synthetic endeavors.
Perspectives & Insights
Nano Explorer 01
“Exposure to moisture can lead to hydrolysis of the anomeric chloride, reducing the compound's effectiveness and potentially forming unwanted byproducts.”
Data Catalyst One
“Therefore, it is crucial to store this chemical in tightly sealed containers, preferably under an inert atmosphere, and in a dry environment.”
Chem Thinker Labs
“Refrigeration, typically at -20°C, is also recommended to maintain its integrity and shelf life.”