Exploring the Chemical Properties of 1-Methylindazole-3-carboxylic Acid
1-Methylindazole-3-carboxylic acid, identified by CAS number 50890-83-0, is a fine chemical with distinct properties that make it invaluable as an intermediate in the pharmaceutical industry, particularly for the synthesis of Granisetron. Understanding these chemical and physical characteristics is crucial for researchers and manufacturers to effectively utilize this compound in their processes.
The compound typically presents as a white to off-white crystalline powder. This specific physical form is a result of its molecular structure and crystallization process, indicating a relatively stable solid state under ambient conditions. Its molecular formula, C9H8N2O2, and a molecular weight of approximately 176.17 g/mol, describe its compact yet functionally rich chemical composition. The melting point, often cited in the range of 213-218°C, further confirms its solid nature and thermal stability, which are important factors during chemical synthesis and handling.
Solubility is another key property. 1-Methylindazole-3-carboxylic acid demonstrates solubility in methanol, a common organic solvent widely used in various chemical reactions and purification steps. This solubility facilitates its incorporation into reaction mixtures and aids in downstream processing. Conversely, it is generally insoluble in water, a characteristic that can be leveraged during extraction and purification procedures to separate it from aqueous byproducts or impurities.
From a quality control perspective, manufacturers pay close attention to parameters like loss on drying and sulfated ash content. For 1-Methylindazole-3-carboxylic acid, these values are typically very low (e.g., loss on drying max 0.5%, sulfated ash max 0.1%), signifying a high degree of purity and minimal residual inorganic contaminants. The assay of the compound is also critical, with specifications often requiring a purity of 97-102.0%. These stringent quality parameters ensure its suitability as a pharmaceutical intermediate, directly impacting the quality and regulatory compliance of the final drug product, Granisetron.
NINGBO INNO PHARMCHEM CO.,LTD. emphasizes these detailed chemical and physical properties when supplying 1-Methylindazole-3-carboxylic acid. By providing compounds that meet these high standards, we support pharmaceutical manufacturers in their critical work of producing essential medications. Understanding these properties is the first step in leveraging this versatile intermediate effectively in complex pharmaceutical synthesis pathways.
The compound typically presents as a white to off-white crystalline powder. This specific physical form is a result of its molecular structure and crystallization process, indicating a relatively stable solid state under ambient conditions. Its molecular formula, C9H8N2O2, and a molecular weight of approximately 176.17 g/mol, describe its compact yet functionally rich chemical composition. The melting point, often cited in the range of 213-218°C, further confirms its solid nature and thermal stability, which are important factors during chemical synthesis and handling.
Solubility is another key property. 1-Methylindazole-3-carboxylic acid demonstrates solubility in methanol, a common organic solvent widely used in various chemical reactions and purification steps. This solubility facilitates its incorporation into reaction mixtures and aids in downstream processing. Conversely, it is generally insoluble in water, a characteristic that can be leveraged during extraction and purification procedures to separate it from aqueous byproducts or impurities.
From a quality control perspective, manufacturers pay close attention to parameters like loss on drying and sulfated ash content. For 1-Methylindazole-3-carboxylic acid, these values are typically very low (e.g., loss on drying max 0.5%, sulfated ash max 0.1%), signifying a high degree of purity and minimal residual inorganic contaminants. The assay of the compound is also critical, with specifications often requiring a purity of 97-102.0%. These stringent quality parameters ensure its suitability as a pharmaceutical intermediate, directly impacting the quality and regulatory compliance of the final drug product, Granisetron.
NINGBO INNO PHARMCHEM CO.,LTD. emphasizes these detailed chemical and physical properties when supplying 1-Methylindazole-3-carboxylic acid. By providing compounds that meet these high standards, we support pharmaceutical manufacturers in their critical work of producing essential medications. Understanding these properties is the first step in leveraging this versatile intermediate effectively in complex pharmaceutical synthesis pathways.
Perspectives & Insights
Data Seeker X
“The assay of the compound is also critical, with specifications often requiring a purity of 97-102.”
Chem Reader AI
“These stringent quality parameters ensure its suitability as a pharmaceutical intermediate, directly impacting the quality and regulatory compliance of the final drug product, Granisetron.”
Agile Vision 2025
“emphasizes these detailed chemical and physical properties when supplying 1-Methylindazole-3-carboxylic acid.”