3-Amino-1,2-Propanediol (CAS 616-30-8), also known as Isoserinol, is a bifunctional organic molecule that holds significant value as a chemical intermediate. Its structure, featuring both an amine group and two hydroxyl groups on a three-carbon chain, imparts unique reactivity and solubility characteristics, making it a sought-after compound in various synthesis applications, particularly within the pharmaceutical and fine chemical industries.

Physically, 3-Amino-1,2-Propanediol is typically described as a colorless to pale yellow liquid, although some sources indicate a melting point around 55-57°C, suggesting it can exist as a viscous solid or liquid depending on temperature and purity. It is readily soluble in water, a property attributed to the hydrophilic hydroxyl and amine groups. The molecule has a relatively high boiling point, around 264-265°C at atmospheric pressure, and a density of approximately 1.175 g/mL at 25°C. These physical properties are crucial considerations for handling, storage, and formulation processes.

The synthesis of 3-Amino-1,2-Propanediol commonly involves the reaction of 3-chloro-1,2-propanediol (CPD) with ammonia. This process, often carried out in an alkaline environment with the addition of a base like sodium hydroxide, can be optimized for yield and purity. Early stages might focus on forming glycidol, followed by an ammonolysis reaction. Manufacturers continuously refine these synthetic routes, employing techniques like microreactor technology and precise control of reaction parameters such as temperature, residence time, and reactant concentrations, to achieve high yields and purity levels of 99.5% or greater.

Understanding these synthesis pathways and physical properties is vital for both manufacturers and end-users. For companies looking to buy 3-Amino-1,2-Propanediol, working with suppliers who can detail their production process and quality control measures provides confidence in the material's suitability for their specific applications. Whether it's for producing pharmaceutical intermediates like contrast agents or for use in advanced material synthesis, a thorough knowledge of the chemical's characteristics is the first step towards successful procurement and application.