For chemists engaged in research and development, a thorough understanding of chemical intermediates is fundamental to successful synthesis. 5-Amino-2,3-dichloropyridine (CAS: 98121-41-6) is a compound that offers significant versatility due to its specific chemical structure and reactivity. This article provides an overview of its properties and typical synthesis approaches, guiding researchers on how to best source this valuable intermediate.

Understanding the Chemical Profile

5-Amino-2,3-dichloropyridine is a chlorinated aminopyridine derivative. Its molecular formula is C5H4Cl2N2, and it typically appears as a solid, ranging in color from white to light yellow or orange. A key physical characteristic is its melting point, which usually falls within the range of 107-112°C. This parameter is often used as an indicator of purity. The presence of the amino group and the two chlorine atoms on the pyridine ring provides multiple sites for chemical reactions, making it a useful building block in a variety of synthetic pathways.

Synthesis and Preparation Methods

The synthesis of 5-Amino-2,3-dichloropyridine often begins with a precursor like 2,3-dichloro-5-nitropyridine. A common method involves the reduction of the nitro group to an amino group. This reduction can be achieved using various reagents and conditions, such as iron powder in acetic acid or catalytic hydrogenation. For example, a typical laboratory synthesis might involve dissolving 2,3-dichloro-5-nitropyridine in a suitable solvent, adding a reducing agent, and then processing the reaction mixture through extraction and purification steps like recrystallization to yield the final product. Yields are often reported around 85% or higher, with purification ensuring the desired purity for subsequent applications.

Applications and Sourcing Considerations

As a pharmaceutical intermediate, 5-Amino-2,3-dichloropyridine is crucial for the synthesis of various APIs. Its utility extends to general organic synthesis, where it serves as a scaffold for building more complex molecules. When procurement managers or research chemists look to buy 5-Amino-2,3-dichloropyridine, they typically seek manufacturers that can guarantee consistent quality and offer competitive pricing. Sourcing from Chinese manufacturers is common due to their production capacity and cost-effectiveness.

Key factors to consider when sourcing include:

  • Purity: Ensuring the product meets the required purity levels (e.g., 98% or higher) is essential for reproducible synthesis.
  • Packaging: Availability of various packaging sizes (from grams to kilograms) is important for different research and production scales.
  • Supplier Reliability: Partnering with manufacturers who provide detailed technical data and samples can streamline the evaluation process.

Obtaining quotes from multiple suppliers is a recommended practice to compare pricing and ensure the best value for this vital chemical intermediate.

By understanding the synthesis and properties of 5-Amino-2,3-dichloropyridine, researchers can confidently incorporate it into their projects, driving innovation in chemistry and pharmaceuticals.