The Chemical Properties and Synthesis of Estrone (CAS 53-16-7)
Estrone, identified by CAS number 53-16-7, is a C18 steroid hormone with a distinctive chemical structure that dictates its biological activity and utility. Its molecular formula is C18H22O2, and it features a phenolic A ring and a ketone group at the 17-carbon position. This structure is key to its role as a hormone and as a versatile chemical intermediate.
The synthesis of Estrone is a fascinating area of organic chemistry. It is biologically produced from androstenedione via aromatase or from estradiol by 17β-hydroxysteroid dehydrogenase, primarily in the ovaries, placenta, and adipose tissues. For pharmaceutical and research purposes, Estrone is synthesized through multi-step chemical processes that often involve complex reactions to achieve high purity.
Key chemical properties of Estrone include its solubility: it is soluble in organic solvents like alcohol and acetone but is almost insoluble in water. This characteristic influences its formulation and application in various research settings and pharmaceutical preparations. Its melting point is typically in the range of 258-260 °C, indicating a stable crystalline solid at room temperature.
The journey from precursor molecules to pure Estrone involves sophisticated synthetic routes. These processes are critical for providing researchers and pharmaceutical companies with a reliable supply of this essential compound. Understanding these synthesis pathways is crucial for quality control and for identifying potential new methods for producing Estrone and its derivatives.
As a leading chemical supplier, we are dedicated to providing Estrone (CAS 53-16-7) that adheres to strict quality standards, ensuring the chemical integrity required for advanced research and drug development. Our focus on precise synthesis and purification guarantees that our Estrone serves effectively as both a critical pharmaceutical intermediate and a reliable research chemical.
The synthesis of Estrone is a fascinating area of organic chemistry. It is biologically produced from androstenedione via aromatase or from estradiol by 17β-hydroxysteroid dehydrogenase, primarily in the ovaries, placenta, and adipose tissues. For pharmaceutical and research purposes, Estrone is synthesized through multi-step chemical processes that often involve complex reactions to achieve high purity.
Key chemical properties of Estrone include its solubility: it is soluble in organic solvents like alcohol and acetone but is almost insoluble in water. This characteristic influences its formulation and application in various research settings and pharmaceutical preparations. Its melting point is typically in the range of 258-260 °C, indicating a stable crystalline solid at room temperature.
The journey from precursor molecules to pure Estrone involves sophisticated synthetic routes. These processes are critical for providing researchers and pharmaceutical companies with a reliable supply of this essential compound. Understanding these synthesis pathways is crucial for quality control and for identifying potential new methods for producing Estrone and its derivatives.
As a leading chemical supplier, we are dedicated to providing Estrone (CAS 53-16-7) that adheres to strict quality standards, ensuring the chemical integrity required for advanced research and drug development. Our focus on precise synthesis and purification guarantees that our Estrone serves effectively as both a critical pharmaceutical intermediate and a reliable research chemical.
Perspectives & Insights
Nano Explorer 01
“Key chemical properties of Estrone include its solubility: it is soluble in organic solvents like alcohol and acetone but is almost insoluble in water.”
Data Catalyst One
“This characteristic influences its formulation and application in various research settings and pharmaceutical preparations.”
Chem Thinker Labs
“Its melting point is typically in the range of 258-260 °C, indicating a stable crystalline solid at room temperature.”