Exploring the Chemical Properties and Synthesis of Valine tert-Butyl Ester Hydrochloride
Understanding the fundamental chemical properties and synthesis pathways of key compounds is essential for chemists and researchers. L-Valine tert-butyl ester hydrochloride (CAS 13518-40-6) is one such compound whose characteristics make it a valuable tool in various chemical disciplines. This article examines its notable physical and chemical properties, along with considerations for its synthesis and reaction suitability.
L-Valine tert-butyl ester hydrochloride typically appears as a white to off-white crystalline powder. Its melting point is reported in the range of 142.0 to 146.0 °C, which is a key identifier for its purity and quality. The compound exhibits slight solubility in common organic solvents like chloroform and methanol, as well as in water. This solubility profile influences its handling and application in different reaction media. The optical activity, [α]20/D +4.4±1° (c=2% in H2O), confirms its chiral nature, preserving the stereochemistry inherited from L-valine. This stereospecificity is critical for applications in stereoselective synthesis.
The 'tert-butyl ester' part of its name refers to the esterification of the carboxyl group with a tert-butyl alcohol moiety. This esterification serves as a protecting group, commonly used in peptide synthesis. It is known for its acid-lability, meaning it can be cleaved off under acidic conditions, typically using trifluoroacetic acid (TFA), to reveal the free carboxylic acid when needed. This selective deprotection is vital for building complex peptide sequences. As a manufacturer in China, NINGBO INNO PHARMCHEM CO.,LTD. focuses on ensuring the integrity of these functional groups during synthesis.
The 'hydrochloride' aspect indicates that the amino group is protonated, forming a salt with hydrochloric acid. This salt formation generally improves the compound's stability and handling properties, making it a free-flowing powder that is easier to weigh and dispense in a laboratory setting. The reaction suitability of L-Valine tert-butyl ester hydrochloride is predominantly in solution-phase peptide synthesis, where its protected form allows for controlled peptide bond formation. Researchers often buy Valine tert-butyl ester hydrochloride from trusted suppliers like NINGBO INNO PHARMCHEM CO.,LTD. for their synthesis needs.
L-Valine tert-butyl ester hydrochloride typically appears as a white to off-white crystalline powder. Its melting point is reported in the range of 142.0 to 146.0 °C, which is a key identifier for its purity and quality. The compound exhibits slight solubility in common organic solvents like chloroform and methanol, as well as in water. This solubility profile influences its handling and application in different reaction media. The optical activity, [α]20/D +4.4±1° (c=2% in H2O), confirms its chiral nature, preserving the stereochemistry inherited from L-valine. This stereospecificity is critical for applications in stereoselective synthesis.
The 'tert-butyl ester' part of its name refers to the esterification of the carboxyl group with a tert-butyl alcohol moiety. This esterification serves as a protecting group, commonly used in peptide synthesis. It is known for its acid-lability, meaning it can be cleaved off under acidic conditions, typically using trifluoroacetic acid (TFA), to reveal the free carboxylic acid when needed. This selective deprotection is vital for building complex peptide sequences. As a manufacturer in China, NINGBO INNO PHARMCHEM CO.,LTD. focuses on ensuring the integrity of these functional groups during synthesis.
The 'hydrochloride' aspect indicates that the amino group is protonated, forming a salt with hydrochloric acid. This salt formation generally improves the compound's stability and handling properties, making it a free-flowing powder that is easier to weigh and dispense in a laboratory setting. The reaction suitability of L-Valine tert-butyl ester hydrochloride is predominantly in solution-phase peptide synthesis, where its protected form allows for controlled peptide bond formation. Researchers often buy Valine tert-butyl ester hydrochloride from trusted suppliers like NINGBO INNO PHARMCHEM CO.,LTD. for their synthesis needs.
Perspectives & Insights
Alpha Spark Labs
“This esterification serves as a protecting group, commonly used in peptide synthesis.”
Future Pioneer 88
“It is known for its acid-lability, meaning it can be cleaved off under acidic conditions, typically using trifluoroacetic acid (TFA), to reveal the free carboxylic acid when needed.”
Core Explorer Pro
“The 'hydrochloride' aspect indicates that the amino group is protonated, forming a salt with hydrochloric acid.”