In the realm of organic chemistry, understanding the properties and reactivity of key intermediates is crucial for successful synthesis. 4-Bromo-2-pentene, identified by CAS number 1809-26-3, is a significant compound that serves as a versatile intermediate in various chemical applications, particularly within the pharmaceutical industry.

Understanding 4-Bromo-2-pentene: Properties and Structure

4-Bromo-2-pentene has the molecular formula C5H9Br and a molecular weight of approximately 149.03 g/mol. Typically presented as a white powder, it exhibits a boiling point of around 114.3°C and is noted for its high purity, often exceeding 99%. This high purity is a critical factor for its application in pharmaceutical synthesis, where precise control over reaction outcomes is essential. The molecule features a five-carbon chain with a double bond between the second and third carbon atoms and a bromine atom attached to the fourth carbon, giving it distinct chemical characteristics.

Synthesis Pathways and Chemical Reactivity

The synthesis of 4-Bromo-2-pentene can be achieved through several organic synthesis routes, often involving the addition of hydrogen bromide to suitable pentene precursors or employing allylic bromination techniques. The precise control of reaction conditions is vital to ensure high yields and minimize the formation of isomeric byproducts. The compound's chemical reactivity is largely determined by the presence of the bromine atom, which acts as a good leaving group, making it highly susceptible to nucleophilic substitution reactions. Furthermore, the bromine atom is situated in an allylic position, which can lead to the formation of stabilized carbocations, influencing reaction pathways. The double bond is also reactive towards electrophilic addition. These reactive sites make 4-Bromo-2-pentene a valuable building block for creating more complex molecules. Many chemical suppliers provide this compound, making it accessible for purchase and research.

Applications in Pharmaceuticals and Fine Chemicals

The primary utility of 4-Bromo-2-pentene lies in its role as a pharmaceutical intermediate. It is frequently used in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs), where its structure can be elaborated to form critical pharmacophores. Its high purity and predictable reactivity make it a preferred choice for synthesizing complex drug molecules. Beyond the pharmaceutical sector, it also finds applications in the broader fine chemical industry as a versatile intermediate for producing specialized chemicals and materials. The price of 4-bromo-2-pentene can vary depending on purity and market demand, making it a key consideration for procurement.

Ensuring Supply Chain Reliability

For companies involved in chemical synthesis, securing a reliable supply of high-quality 4-bromo-2-pentene is crucial. Reputable chemical suppliers offer this compound with detailed specifications, ensuring consistency and traceability. Understanding the market dynamics, including the typical price of 4-bromo-2-pentene and the availability from various manufacturers, is important for maintaining efficient R&D and production processes.

In summary, 4-Bromo-2-pentene (CAS 1809-26-3) is a vital intermediate whose chemical properties and accessibility make it indispensable for advancements in pharmaceutical synthesis and the broader chemical industry.