In today's globalized chemical market, sourcing high-quality raw materials efficiently is a critical challenge for R&D departments and procurement managers. For specialized compounds like N-Acetyl-L-aspartic acid 4-tert-butyl ester (CAS 117833-18-8), China offers a robust manufacturing landscape. This article provides insights for buyers looking to procure this essential pharmaceutical intermediate, focusing on quality, pricing, and supplier selection.

Understanding the Product: N-Acetyl-L-aspartic Acid 4-tert-butyl Ester

This compound, often abbreviated as ac-asp(otbu)-oh, is a protected derivative of L-aspartic acid. Its molecular formula is C10H17NO5, with a molecular weight of 231.24600. The key feature is the presence of a tert-butyl ester protecting the side-chain carboxyl group and an acetyl group protecting the alpha-amino group. These protective functionalities are crucial for its application as a building block in peptide synthesis and as an intermediate in the manufacturing of Active Pharmaceutical Ingredients (APIs).

The China Advantage: Quality and Cost-Effectiveness

China's chemical manufacturing sector is known for its ability to produce a wide range of complex organic molecules at competitive prices. When considering where to buy N-Acetyl-L-aspartic acid 4-tert-butyl ester, Chinese suppliers often provide a compelling combination of quality and cost savings. However, it is vital for procurement professionals to conduct thorough due diligence.

Key Factors for Buyers When Sourcing from China:

  • Purity Verification: Always request a detailed Certificate of Analysis (CoA) to confirm the purity level (e.g., ≥98%). This is paramount for pharmaceutical applications where deviations can impact efficacy and regulatory compliance.
  • Supplier Reputation: Research potential suppliers. Look for established manufacturers with a history of reliable supply and positive customer feedback. Online platforms and industry directories can be valuable resources for finding reputable manufacturers and distributors.
  • Technical Data and Support: Ensure the supplier can provide comprehensive technical data sheets and is responsive to queries regarding the product's specifications, storage requirements (typically 2-8°C for this compound), and handling.
  • Minimum Order Quantities (MOQ) and Lead Times: Understand the supplier's MOQ and estimated lead times to align with your project timelines and inventory management needs.
  • Sample Testing: Before placing a large order, it is highly recommended to purchase samples and conduct internal testing to verify quality and suitability for your specific synthesis process.

Applications and Why Buy This Specific Intermediate

The primary application for N-Acetyl-L-aspartic acid 4-tert-butyl ester is in peptide synthesis, where it serves as a crucial protected amino acid. Researchers involved in developing peptide-based drugs or studying protein structures will find this intermediate indispensable. Its structure allows for controlled coupling reactions, essential for building precise peptide sequences. For these applications, securing a consistent supply of high-quality material is a strategic imperative.

Conclusion: Strategic Procurement for Success

Sourcing N-Acetyl-L-aspartic acid 4-tert-butyl ester from China can offer significant advantages when approached strategically. By focusing on purity, supplier reliability, and understanding the technical requirements of this key pharmaceutical intermediate, procurement managers can ensure they are acquiring a high-quality product that supports their R&D goals. When you need to buy this vital compound, thorough vetting of your Chinese suppliers will pave the way for successful and efficient project execution.