In the realm of advanced organic synthesis and pharmaceutical research, specialized chemical intermediates are the bedrock upon which innovation is built. N-Acetyl-L-aspartic acid 4-tert-butyl ester (CAS 117833-18-8), often referred to by its shorthand ac-asp(otbu)-oh, is one such versatile building block. Its unique structural features, particularly the protecting groups on its amino and carboxyl functionalities, make it a preferred choice for chemists aiming for precise synthesis of complex molecules.

Chemical Profile and Synthesis Advantages

The chemical identity of N-Acetyl-L-aspartic acid 4-tert-butyl ester is defined by its molecular formula, C10H17NO5, and a molecular weight of approximately 231.25 g/mol. As a white powder, it is typically handled with care and stored under controlled conditions, usually between 2-8°C, to maintain its integrity. The strategic placement of the N-acetyl group on the alpha-amino nitrogen and the tert-butyl ester on the beta-carboxyl group provides crucial advantages:

  • Selective Reactivity: The protecting groups allow for selective reactions at specific sites of the molecule. This is fundamental in multi-step syntheses, preventing unintended reactions and ensuring the desired product is formed.
  • Ease of Deprotection: The tert-butyl ester is a common protecting group in organic chemistry due to its stability during many reactions, followed by facile removal under mild acidic conditions (e.g., using trifluoroacetic acid). This selectivity simplifies downstream processing.
  • Chiral Integrity: As a derivative of L-aspartic acid, it maintains its chiral center, which is essential for synthesizing stereochemically pure compounds, particularly in pharmaceutical applications where enantiomeric purity is critical.

When scientists decide to buy this compound, they are investing in a tool that significantly streamlines complex synthetic routes, making R&D more efficient.

Applications in Research and Development

The primary application for N-Acetyl-L-aspartic acid 4-tert-butyl ester lies in peptide synthesis. It serves as a protected amino acid residue that can be reliably incorporated into growing peptide chains using standard coupling reagents. This makes it a staple for researchers developing peptide-based therapeutics, diagnostics, or research tools.

Beyond peptide chemistry, its utility extends to general organic synthesis as a chiral building block. Chemists can leverage its functional groups to construct diverse organic molecules, including pharmaceutical intermediates, fine chemicals, and materials with specific properties. For procurement managers seeking such versatile intermediates, identifying suppliers who offer high-purity grades (≥98%) is key to ensuring reproducible research outcomes.

Sourcing and Supplier Considerations

Finding a reliable supplier is crucial when you need to buy N-Acetyl-L-aspartic acid 4-tert-butyl ester. Manufacturers specializing in amino acid derivatives and pharmaceutical intermediates, particularly those based in China, often provide the required quality and scale. When evaluating suppliers, consider their quality control processes, technical support, and ability to provide consistent supply. A competitive price is important, but should not come at the expense of product purity or reliability.

Conclusion: A Foundation for Chemical Innovation

N-Acetyl-L-aspartic acid 4-tert-butyl ester represents more than just a chemical compound; it is a fundamental tool for innovation in chemistry. Its well-designed protection strategy and chiral nature empower researchers to achieve complex synthetic goals. For those in the field, securing a dependable supply of this intermediate is a critical step towards successful R&D outcomes.