For organic chemists and researchers engaged in innovative synthesis, understanding the properties and potential of key building blocks is essential. 3-Hydroxypyridine, identified by CAS number 109-00-2, is a compound that offers considerable versatility in organic synthesis due to its unique chemical structure and reactivity. This guide provides practical insights into utilizing 3-Hydroxypyridine in various synthetic pathways and offers advice on sourcing this crucial reagent.

The Chemical Versatility of 3-Hydroxypyridine

3-Hydroxypyridine, also known as 3-pyridinol, is an aromatic heterocycle that features a hydroxyl group attached to the pyridine ring. This hydroxyl group acts as a reactive site, making the molecule amenable to a range of chemical transformations. Chemists commonly employ it in:

  • Nucleophilic Substitution Reactions: The hydroxyl group can be readily substituted or functionalized, allowing for the introduction of diverse chemical moieties.
  • Condensation Reactions: It can participate in condensation reactions to form new carbon-heteroatom bonds, crucial for building larger, more complex molecular structures.
  • As a Ligand in Catalysis: The pyridine nitrogen and the hydroxyl oxygen can coordinate with metal ions, suggesting potential applications as ligands in catalytic systems.

Its utility extends to the synthesis of pharmaceuticals, agrochemicals, and specialty materials, making it a staple in many research and development laboratories.

Key Applications in Organic Synthesis Projects

Researchers often utilize 3-Hydroxypyridine for:

  • Synthesis of Bioactive Compounds: It serves as a scaffold for creating molecules with potential biological activity, such as anti-inflammatory agents or antimicrobial substances.
  • Development of Novel Materials: Its structure can be incorporated into polymers or functional materials with specific electronic or optical properties.
  • Creation of Complex Heterocycles: It is a valuable starting material for building more intricate heterocyclic systems common in medicinal chemistry.

Purchasing 3-Hydroxypyridine: What Buyers Need to Know

When looking to buy 3-Hydroxypyridine for your synthesis projects, consider the following:

  • Purity: For reliable synthesis outcomes, especially in sensitive reactions, high purity (e.g., ≥98%) is essential. Always check the product specifications and CoA.
  • Supplier Reputation: Partner with established manufacturers and suppliers who can provide consistent quality and reliable delivery. Manufacturers in China are often a good source for cost-effective, high-quality intermediates like CAS 109-00-2.
  • Pricing: Compare quotes from different suppliers to ensure you are obtaining a competitive price, particularly for larger research quantities or pilot-scale production.
  • Availability: Ensure the supplier has sufficient stock or can commit to timely delivery for your project timelines.

Conclusion

3-Hydroxypyridine is a valuable tool for the modern organic chemist, offering a gateway to diverse and complex molecular structures. By understanding its reactivity and carefully selecting a reliable supplier, researchers can effectively leverage this intermediate to drive innovation in their synthesis projects. When planning your next chemical synthesis endeavor, consider purchasing 3-Hydroxypyridine from a trusted manufacturer to ensure the success of your research.