The development and production of modern pharmaceuticals involve intricate chemical synthesis pathways, where each intermediate plays a crucial role. Anastrozole, a significant drug in the management of hormone-receptor-positive breast cancer, is synthesized through a multi-step process that heavily relies on specific chemical building blocks. One of the key intermediates in this synthesis is 2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile), identified by CAS Number 120511-84-4. This article explores the manufacturing aspects of this intermediate and guides professionals on how to efficiently buy it.

The Chemical Structure and Role of the Intermediate

2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile) (C15H17BrN2) is a brominated organic compound featuring nitrile groups. Its molecular weight is approximately 305.21 g/mol. The compound typically presents as a white to off-white powder, and its chemical structure is specifically designed to facilitate the subsequent reactions leading to the formation of Anastrozole. The presence of the bromomethyl group is a critical functional element for its role in the synthetic pathway.

Manufacturing and Quality Specifications

For pharmaceutical manufacturers, the quality of intermediates is as critical as the quality of the final API. The synthesis of 2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile) requires precise control over reaction conditions to achieve high purity. A typical specification for this intermediate is an assay of ≥98.0%. This high level of purity is essential to minimize the formation of unwanted by-products during Anastrozole synthesis, ensuring the efficacy and safety of the final drug. Manufacturers must ensure consistent batch-to-batch quality, a factor that underscores the importance of selecting experienced production partners.

Sourcing Strategies for Buyers

When your organization needs to buy 2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile), a strategic approach to sourcing is vital. Consider these points:

  • Supplier Selection: Identify manufacturers with a strong reputation in producing pharmaceutical intermediates. Many global buyers source from China, which possesses a significant chemical manufacturing infrastructure.
  • Product Quality Verification: Always request and thoroughly review the Certificate of Analysis (CoA) to confirm the product meets specifications, particularly regarding purity (≥98.0%).
  • Pricing and Lead Times: Obtain detailed quotations and discuss lead times to align with your production schedules. Competitive pricing is also a key consideration.
  • Technical Support: Ensure the supplier can offer technical assistance and comprehensive documentation, such as Safety Data Sheets (SDS).

Why Partner with a Dedicated Manufacturer?

As a specialized manufacturer, we are dedicated to providing high-quality pharmaceutical intermediates. Our capabilities allow us to produce 2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile) meeting stringent purity requirements. We understand the demands of the pharmaceutical industry and are committed to being a reliable supplier. If you are looking to buy this essential intermediate, we encourage you to reach out to us to discuss your specific needs and how we can support your manufacturing process.

In conclusion, the chemical synthesis of Anastrozole is a sophisticated process that relies on the quality and availability of key intermediates like 2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile). By focusing on sourcing from reputable manufacturers, particularly those with strong production capabilities, pharmaceutical companies can ensure the successful and compliant manufacturing of Anastrozole.