For procurement managers in the pharmaceutical sector, securing a consistent and high-quality supply of critical intermediates is paramount. One such compound is 2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile), primarily known for its role as a key intermediate in the synthesis of Anastrozole. If you are looking to buy this essential chemical, understanding the market, reliable manufacturers, and key specifications will be crucial for your purchasing decisions.

Understanding the Intermediate's Significance

Anastrozole is a well-established aromatase inhibitor used in the treatment of breast cancer. The synthesis of Anastrozole relies heavily on intermediates like 2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile) (CAS No: 120511-84-4). This compound, often appearing as a white to off-white powder, possesses specific chemical properties that make it indispensable in the multi-step synthesis of the Active Pharmaceutical Ingredient (API). Its molecular formula is C15H17BrN2, with a molecular weight of approximately 305.21 g/mol. Ensuring the purity of this intermediate, typically specified at ≥98.0%, is a primary concern for manufacturers to guarantee the efficacy and safety of the final pharmaceutical product.

Key Considerations for Procurement Managers

When sourcing this vital intermediate, procurement managers should focus on several key areas:

  • Purity and Specifications: Always verify the Certificate of Analysis (CoA) to confirm the purity (≥98.0%) and other critical specifications like appearance and assay. This directly impacts the quality of the Anastrozole produced.
  • Supplier Reliability: Establishing a relationship with a reputable manufacturer and supplier is vital. Look for suppliers with a proven track record in producing pharmaceutical intermediates, ideally with strong manufacturing capabilities in China, known for its significant chemical production base.
  • Pricing and Availability: Competitive pricing is a significant factor. Obtain quotes from multiple suppliers to ensure you are getting market-competitive rates. Furthermore, discuss lead times and ensure the supplier can meet your ongoing production demands.
  • Regulatory Compliance: While this is an intermediate, understanding its handling and any relevant regulatory information is important. The supplier should be able to provide necessary safety data sheets (SDS) and support your quality assurance processes.

Why Buy from a Dedicated Manufacturer?

Choosing a dedicated manufacturer rather than a general distributor can offer distinct advantages. Manufacturers often have more control over the production process, ensuring consistent quality and the ability to meet specific client requirements. They can also provide more detailed technical support and may offer better pricing due to direct production. When you aim to buy 2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile), partnering with an experienced chemical manufacturer in China ensures you are tapping into a robust supply chain designed for pharmaceutical needs.

In summary, procurement professionals looking to buy the Anastrozole intermediate must prioritize purity, supplier reliability, and competitive pricing. By carefully evaluating potential manufacturers and suppliers, you can secure a consistent supply of this crucial chemical, supporting the efficient and high-quality production of Anastrozole. For your pharmaceutical intermediate needs, consider established chemical suppliers in China to source this critical building block.