The intricate world of chemical synthesis relies on a foundation of precise intermediates, and N-(2,6-Dimethylphenyl)chloroacetamide is a prime example of such a crucial compound. Its role in the pharmaceutical industry, particularly in the creation of essential drugs, underscores the importance of understanding its synthesis, properties, and applications. For R&D scientists and chemical engineers, gaining insight into this intermediate provides a pathway to optimizing drug development and manufacturing processes. This article delves into the chemical synthesis of N-(2,6-Dimethylphenyl)chloroacetamide and its significant contributions to the pharmaceutical sector.

N-(2,6-Dimethylphenyl)chloroacetamide, identified by its CAS number 1131-01-7, is synthesized through well-established chemical pathways. Typically, the process involves the reaction of 2,6-dimethylaniline with chloroacetyl chloride, often in the presence of a base and a suitable solvent. The resulting compound, a white to off-white powder, possesses a purity level of at least 98.0%, making it highly desirable for pharmaceutical synthesis. Its molecular formula, C10H12ClNO, and molecular weight of 197.661 are key identifiers for its chemical identity and reactivity.

The physical and chemical properties of N-(2,6-Dimethylphenyl)chloroacetamide are critical for its effective use. With a melting point of 150-151 °C, it is a stable solid at room temperature, simplifying storage and handling. Its density of approximately 1.2±0.1 g/cm³ and a boiling point around 316.8±30.0 °C indicate robustness under various processing conditions. These attributes are vital for chemists aiming to control reaction parameters and achieve reproducible results in drug synthesis.

The paramount application of N-(2,6-Dimethylphenyl)chloroacetamide is as an intermediate in the synthesis of pharmaceuticals. It serves as a key building block for Ranolazine, a medication prescribed for chronic angina, and Lidocaine, a widely used local anesthetic. The presence of the reactive chloroacetamide group allows for nucleophilic substitution reactions, a fundamental step in creating the complex molecular structures of these drugs. Pharmaceutical companies looking to buy this intermediate must ensure it meets the required assay and purity specifications to guarantee the quality of their final drug products.

For those involved in the pharmaceutical supply chain, understanding the sourcing landscape is important. Many global pharmaceutical firms rely on manufacturers in China for their supply of N-(2,6-Dimethylphenyl)chloroacetamide. Companies like NINGBO INNO PHARMCHEM CO.,LTD. specialize in the production of such fine chemicals, offering high-purity products at competitive prices. Their expertise in chemical synthesis and commitment to quality assurance make them a valuable partner for any pharmaceutical company requiring this intermediate.

In conclusion, N-(2,6-Dimethylphenyl)chloroacetamide is a testament to the importance of well-characterized and readily available chemical intermediates in pharmaceutical synthesis. Its precise synthesis, predictable properties, and critical role in creating life-saving medications highlight why it remains a sought-after compound. For businesses seeking to procure this vital chemical, partnering with experienced manufacturers ensures the quality and consistency necessary for successful drug production.