For researchers and chemists engaged in advanced synthesis, understanding the chemical versatility of key intermediates is crucial. 5-Bromoindole-2-carboxylic acid (CAS: 7254-19-5) stands out as a prime example, offering a rich platform for diverse chemical transformations. This article delves into its chemical properties, reactivity, and broad applications in research and development, guiding you on how to procure this essential compound.

Chemical Properties and Reactivity

5-Bromoindole-2-carboxylic acid is a white to light yellow solid characterized by its indole core, a bromine substituent at the 5-position, and a carboxylic acid group at the 2-position. The presence of the bromine atom makes it amenable to various palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings, allowing for the introduction of a wide range of functional groups or complex molecular fragments. The carboxylic acid group, on the other hand, can undergo esterification, amidation, and reduction, providing further avenues for structural modification. This dual reactivity makes it an extremely valuable building block in multistep syntheses.

Applications Driving R&D Innovation

The inherent reactivity of 5-Bromoindole-2-carboxylic acid translates into a broad spectrum of applications across scientific disciplines:

  • Pharmaceutical Synthesis: It is a foundational intermediate for creating novel drug candidates. Researchers utilize it to build molecules targeting cancer, inflammatory diseases, and infections. For example, its role in synthesizing inhibitors for enzymes like MMP-13 and IDO is well-documented.
  • Organic Synthesis: Beyond pharmaceuticals, it's employed in general organic synthesis for creating complex heterocyclic compounds and functional materials.
  • Agrochemical Research: Its indole structure can be modified to develop new generations of pesticides and herbicides with improved efficacy and environmental profiles.
  • Materials Science: The electronic and optical properties of indole derivatives are being explored for use in organic electronics and fluorescent probes.

When planning to buy 5-Bromoindole-2-carboxylic acid, specifying the CAS number 7254-19-5 and desired purity ensures you receive the appropriate grade for your R&D objectives. Reliable manufacturers are key to obtaining consistent quality.

Procuring 5-Bromoindole-2-carboxylic Acid for Your Lab

Securing a reliable supply of this intermediate is essential for seamless R&D operations. When you need to purchase 5-Bromoindole-2-carboxylic acid, consider the following:

  • Supplier Reputation: Opt for established chemical suppliers with expertise in intermediates and fine chemicals.
  • Quality Documentation: Always request Certificates of Analysis (CoA) and Safety Data Sheets (SDS).
  • Pricing and Volume: Compare pricing across different suppliers and inquire about bulk discounts for larger quantities.
  • Technical Support: Choose manufacturers who can offer technical assistance regarding product specifications and handling.

NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer committed to providing high-quality chemical intermediates. We offer 5-Bromoindole-2-carboxylic acid and a wide range of other specialized chemicals. Contact us to discuss your specific needs and receive a competitive quote, ensuring your research progresses without interruption.