In the realm of organic synthesis, the availability of well-characterized and reactive intermediates is fundamental to driving innovation. 5-Bromoindole-2-carboxylic acid (CAS: 7254-19-5) exemplifies such a compound, offering a unique structural motif that unlocks a wide array of chemical transformations. This article provides an in-depth look at its synthesis, details its significant applications, and guides researchers in selecting a reliable manufacturer for consistent sourcing.

Synthetic Approaches to 5-Bromoindole-2-carboxylic Acid

The preparation of 5-Bromoindole-2-carboxylic acid typically begins with readily available indole precursors. A common route involves the electrophilic bromination of indole-2-carboxylic acid or its derivatives, followed by necessary functional group transformations. Alternatively, starting from a pre-brominated benzene derivative and constructing the indole ring system can also yield the desired product. One widely employed method in laboratory and industrial settings is the ester hydrolysis route, where ethyl 5-bromoindole-2-carboxylate is treated with a base or acid to cleave the ester linkage, yielding the free carboxylic acid. The efficiency and yield of these processes are critical factors for manufacturers aiming to supply this intermediate at competitive prices.

Diverse Applications in Chemical Synthesis

The chemical structure of 5-Bromoindole-2-carboxylic acid makes it a highly sought-after intermediate in various fields:

  • Drug Synthesis: It is a cornerstone in the development of numerous pharmaceutical agents. Its indole scaffold is found in compounds with anti-cancer, anti-inflammatory, and antiviral properties. For example, it's used to synthesize molecules that inhibit crucial enzymes or receptors involved in disease progression.
  • Agrochemical Development: The compound's structural features can be exploited to create novel pesticides and herbicides, contributing to improved crop protection solutions.
  • Advanced Materials: In material science, indole derivatives are explored for their electronic and optical properties, making this compound a potential precursor for new functional materials.
  • Research Reagent: As a versatile building block, it is widely used in academic and industrial research labs for exploring new reaction methodologies and discovering novel chemical entities.

When you intend to buy 5-Bromoindole-2-carboxylic acid, always confirm the CAS number (7254-19-5) and purity specifications from your supplier. A reliable manufacturer will provide detailed technical data to support your research.

Choosing the Right Manufacturer and Supplier

For R&D scientists and procurement specialists, securing a consistent and high-quality supply of 5-Bromoindole-2-carboxylic acid is paramount. Reputable chemical suppliers, including those specializing in pharmaceutical intermediates and fine chemicals, offer this product. Key considerations when selecting a supplier include:

  • Quality Assurance: Certificates of Analysis (CoA) and robust quality control processes.
  • Scalability: Ability to provide materials in various quantities, from grams to bulk.
  • Technical Expertise: Support and guidance on product use and specifications.
  • Global Reach: Efficient logistics for timely delivery worldwide.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-purity chemical intermediates. We invite you to explore our product catalog and request a quote for 5-Bromoindole-2-carboxylic acid, your essential partner in chemical innovation.