In the realm of organic chemistry and pharmaceutical research, certain molecules stand out for their versatility and utility as building blocks. 3-Bromoisoquinoline, identified by its CAS number 34784-02-6, is one such compound, offering chemists a powerful tool for synthesizing a wide array of complex organic structures. This article delves into its chemical properties and explores its applications in research and development (R&D), highlighting why it's a sought-after intermediate.

Understanding the Chemical Profile of 3-Bromoisoquinoline

At its core, 3-Bromoisoquinoline is a heterocyclic aromatic compound derived from isoquinoline. The key to its reactivity lies in the presence of a bromine atom at the 3-position of the isoquinoline ring system. Let's break down its essential chemical characteristics:

  • Structure and Reactivity: The isoquinoline moiety is an aromatic bicyclic system consisting of a benzene ring fused with a pyridine ring. The bromine atom at position 3 is an excellent leaving group, making this position highly reactive towards nucleophilic substitution and, more importantly, towards organometallic cross-coupling reactions.
  • Purity and Physical State: For R&D purposes, high purity is crucial. Typically, 3-Bromoisoquinoline is supplied with a minimum purity of 99%. It presents as a white to light brown solid, with a melting point in the range of 63-64 °C. This solid form makes it relatively easy to handle and weigh accurately in laboratory settings.
  • Molecular Properties: Its molecular formula is C9H6BrN, and its molecular weight is approximately 208.05 g/mol. These parameters are fundamental for stoichiometric calculations in any synthetic endeavor.
  • Solubility and Stability: While specific solubility data can vary, it generally exhibits solubility in common organic solvents used in synthesis, such as dichloromethane, ethyl acetate, and ethers. Proper storage in a cool, dark, and dry place is essential to maintain its stability and prevent degradation.

Applications in Research and Development

The utility of 3-Bromoisoquinoline in R&D stems from its adaptability in synthesis. Researchers leverage it for:

  • Catalytic Cross-Coupling Reactions: This is arguably the most significant application. The bromine atom readily participates in palladium-catalyzed reactions like the Suzuki-Miyaura coupling (reaction with organoboron compounds), Sonogashira coupling (reaction with terminal alkynes), Heck reaction (reaction with alkenes), and Buchwald-Hartwig amination (reaction with amines). These reactions are foundational for building complex molecular architectures found in pharmaceuticals, agrochemicals, and advanced materials. For example, using this intermediate, researchers can efficiently attach various aryl, alkyl, alkenyl, or alkynyl groups to the isoquinoline core.
  • Synthesis of Bioactive Compounds: The isoquinoline scaffold is prevalent in many natural products and pharmaceuticals exhibiting a wide range of biological activities, including anticancer, antimicrobial, and antiviral properties. 3-Bromoisoquinoline serves as a key precursor for synthesizing novel isoquinoline-based drug candidates or analogs of existing bioactive compounds.
  • Development of Novel Heterocyclic Systems: Beyond direct API synthesis, it can be used to construct more complex fused heterocyclic systems or to explore new synthetic methodologies for creating diverse chemical libraries.
  • Material Science Explorations: Although primarily known for its role in medicinal chemistry, isoquinoline derivatives can also exhibit interesting photophysical properties, potentially finding applications in organic electronics or sensing materials.

Sourcing for Your R&D Needs: Why Choose a Reliable Supplier?

For research laboratories, obtaining 3-Bromoisoquinoline of high purity and consistent quality is paramount for ensuring reproducible results. When you need to buy this compound, looking for a supplier that offers:

  • Guaranteed Purity: Certificates of Analysis (CoA) confirming 99%+ purity are essential.
  • Free Samples: The ability to obtain free samples for initial screening and method development can save significant R&D budget.
  • Responsive Customer Service: Quick answers to inquiries about availability, specifications, and shipping are critical for time-sensitive research projects.
  • Global Reach: Suppliers who can ship efficiently to your location ensure minimal delays in your research timeline.

As a dedicated manufacturer, we understand the demands of R&D and strive to provide 3-Bromoisoquinoline (CAS 34784-02-6) that meets these exacting standards, empowering chemists worldwide to push the boundaries of discovery.