Understanding the fundamental chemistry of key intermediates is crucial for chemists and manufacturers engaged in organic synthesis. 3-Chloro-1-propanol (CAS 627-30-5) is one such compound, a bifunctional molecule that offers a rich landscape for chemical transformations. This article delves into the properties and synthesis applications of 3-Chloro-1-propanol, highlighting its value as a chemical building block and where to buy it.

3-Chloro-1-propanol is characterized by its colorless liquid appearance and a molecular formula of C3H7ClO, with a molecular weight of approximately 94.54 g/mol. Its structure features a primary alcohol group and a primary alkyl chloride. This combination of functional groups dictates its reactivity. The hydroxyl group can undergo typical alcohol reactions like esterification or etherification, while the chlorine atom is susceptible to nucleophilic substitution reactions.

The reactivity of the chlorine atom makes 3-Chloro-1-propanol a valuable electrophile in organic synthesis. For instance, it can react with amines to form amino alcohols, with thiols to form thioethers, or with cyanide ions to extend the carbon chain. These reactions are fundamental in building more complex molecules. Researchers looking to buy this intermediate can leverage these reactions to synthesize a variety of downstream products, including pharmaceuticals, agrochemicals, and specialty materials.

Its application as a pharmaceutical intermediate is particularly noteworthy. It serves as a precursor in the synthesis of various APIs. For example, it is an intermediate in the synthesis of Nefenavir and can be used to prepare 3-Chloropropyl Chloroformate. The high purity often required for these applications means that sourcing from reputable manufacturers who adhere to strict quality control is essential. When you buy 3-Chloro-1-propanol, ensuring its chemical integrity is key to successful synthesis.

The compound is typically synthesized from ethylene, formaldehyde, and hydrogen chloride. Its physical properties, such as a boiling point of around 160-162 °C and a density of approximately 1.131 g/mL, are important considerations for process design. As a combustible liquid with specific hazard classifications, proper handling and storage are necessary. Manufacturers provide detailed safety data to guide users.

In essence, 3-Chloro-1-propanol (CAS 627-30-5) is a versatile and important chemical intermediate. Its bifunctional nature makes it a valuable tool in organic synthesis for a wide range of applications. For chemists and manufacturers seeking to buy this compound, understanding its chemical properties and sourcing from reliable suppliers is paramount to achieving their synthetic goals.