The efficacy of modern pharmaceuticals often hinges on intricate molecular structures, particularly those involving specific stereochemistry. Bortezomib, a dual-acting proteasome inhibitor widely used in cancer therapy, is a prime example. Its successful synthesis requires precise control over multiple chiral centers, a feat often accomplished through the strategic use of chiral intermediates. (1R,2R,3S,5R)-(-)-2,3-Pinanediol, a specialized compound offered by NINGBO INNO PHARMCHEM CO.,LTD., stands out as a crucial building block in this complex chemical pathway.

Unveiling the Properties of (1R,2R,3S,5R)-(-)-2,3-Pinanediol

With CAS Number 22422-34-0 and the molecular formula C10H18O2, (1R,2R,3S,5R)-(-)-2,3-Pinanediol is a white solid characterized by its specific chiral configuration. Its physical and chemical properties, including a boiling point of 101-102°C (at 1 mmHg) and a melting point of 55-59°C, are well-documented. The emphasis on high purity (≥99%) and minimal impurities (≤0.05%) by manufacturers like NINGBO INNO PHARMCHEM ensures its suitability for demanding synthetic processes. This controlled quality is essential when producing pharmaceutical ingredients where even trace impurities can impact efficacy or safety.

Mechanism in Bortezomib Synthesis

The synthesis of Bortezomib involves several stereoselective steps. (1R,2R,3S,5R)-(-)-2,3-Pinanediol often functions as a chiral auxiliary or precursor, guiding the stereochemical outcome of reactions to ensure the formation of the correct isomer of Bortezomib. Its unique bicyclic structure and the presence of hydroxyl groups allow it to participate in reactions that establish the critical stereocenters present in the final drug molecule. Researchers looking to buy this intermediate are often focused on its ability to reliably introduce or control chirality in their synthesis, ultimately impacting the overall yield and enantiomeric purity of the Bortezomib API.

NINGBO INNO PHARMCHEM: Your Source for High-Quality Intermediates

As a dedicated manufacturer and supplier from China, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing researchers and pharmaceutical manufacturers with access to essential chemical building blocks. Our offerings of (1R,2R,3S,5R)-(-)-2,3-Pinanediol feature:

  • Exceptional Purity: Consistently delivering ≥99% purity for your critical synthetic needs.
  • Reliable Manufacturing: We are a trusted producer with stringent quality control measures in place.
  • Competitive Market Price: Offering cost-effective solutions for bulk purchases, making it accessible for widespread research and production. Inquire for a quote.
  • Stable Supply Chain: Ensuring that you can buy this vital intermediate without interruption.

Understanding the intricate chemical requirements for drugs like Bortezomib highlights the importance of sourcing high-quality intermediates. NINGBO INNO PHARMCHEM CO.,LTD. is your reliable partner in China for (1R,2R,3S,5R)-(-)-2,3-Pinanediol, supporting your efforts in advancing pharmaceutical science and manufacturing.