In the development of life-saving pharmaceuticals, the precise synthesis of complex molecules is critical. Bortezomib, a cornerstone treatment for multiple myeloma and mantle cell lymphoma, relies on specific chiral intermediates to achieve its therapeutic efficacy. Among these, (1R,2R,3S,5R)-(-)-2,3-Pinanediol (CAS: 22422-34-0) plays a pivotal role. As a leading manufacturer and supplier of high-quality pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing this essential building block to researchers and pharmaceutical companies worldwide.

Understanding the Chemical Significance

(1R,2R,3S,5R)-(-)-2,3-Pinanediol, characterized as a white solid, possesses a unique stereochemical configuration vital for the asymmetric synthesis of Bortezomib. Its chemical formula is C10H18O2, and its physical properties, such as a melting point of 55-59°C and a boiling point of 101-102°C at 1 mmHg, are well-defined. The high purity (≥99%) and controlled low impurity levels (≤0.05%) offered by NINGBO INNO PHARMCHEM ensure that it serves as an ideal starting material or intermediate, minimizing side reactions and maximizing the yield and purity of the final Active Pharmaceutical Ingredient (API).

The Synthesis Pathway to Bortezomib

Bortezomib's therapeutic action as a proteasome inhibitor is intricately linked to its specific molecular structure, which includes multiple chiral centers. The introduction of chirality early in the synthesis, often through the use of chiral auxiliaries or intermediates like (1R,2R,3S,5R)-(-)-2,3-Pinanediol, is fundamental to achieving the correct stereoisomer. This pinanediol derivative is frequently employed to direct the stereochemical outcome of subsequent reaction steps, ultimately leading to the formation of the biologically active form of Bortezomib. Understanding how to buy this key intermediate is crucial for efficient drug manufacturing.

Why NINGBO INNO PHARMCHEM is Your Preferred Supplier

As a professional manufacturer and supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. offers distinct advantages to pharmaceutical clients seeking to purchase (1R,2R,3S,5R)-(-)-2,3-Pinanediol:

  • Guaranteed Purity and Quality: We ensure that our product consistently meets the ≥99% purity standard, with minimal moisture (0.1%) and impurities (0.05%), critical for sensitive pharmaceutical synthesis.
  • Competitive Pricing and Bulk Options: We understand the importance of cost-effectiveness in API production. Our pricing structure for (1R,2R,3S,5R)-(-)-2,3-Pinanediol is competitive, and we offer flexible options for bulk purchases to support large-scale manufacturing. Inquire about our latest price for your supply needs.
  • Reliable Sourcing from China: With a stable and robust supply chain, we provide a consistent flow of this vital intermediate, ensuring your production schedules are met without interruption. We are a trusted manufacturer for your sourcing requirements.
  • Expert Technical Support: Our team of chemists is available to provide technical information and support regarding the application of (1R,2R,3S,5R)-(-)-2,3-Pinanediol in your synthesis pathways.

For companies engaged in the synthesis of Bortezomib or other complex chiral pharmaceuticals, securing a high-quality supply of (1R,2R,3S,5R)-(-)-2,3-Pinanediol is a critical step. NINGBO INNO PHARMCHEM CO.,LTD. is committed to being your reliable partner, providing the essential chemical building blocks needed for groundbreaking pharmaceutical innovation.