Dronedarone, a benzofuran derivative, is a cornerstone in the management of atrial fibrillation, offering a vital therapeutic option for patients. Its complex molecular structure is achieved through a series of carefully orchestrated chemical reactions, with key intermediates playing indispensable roles. Among these, (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone, identifiable by its CAS number 141645-16-1, stands out as a crucial building block.

The synthesis of Dronedarone involves constructing its intricate polycyclic structure. (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone provides a significant portion of this framework, specifically the benzofuran moiety with strategically placed functional groups. Its chemical name itself reveals key structural features: a butyl group attached to the benzofuran ring, a nitro group at the 5-position, and a benzoyl substituent linked to a hydroxyphenyl group. These features are precisely what the Dronedarone molecule requires, making this intermediate an efficient starting point for further chemical transformations.

The importance of this intermediate extends beyond its structural contribution. The purity and quality of (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone directly influence the efficiency and outcome of subsequent synthesis steps. A compound with a minimum purity of ≥99% and carefully controlled impurities ensures that the reactions proceed smoothly, leading to higher yields and a cleaner final product. This is why pharmaceutical companies, when they look to buy this compound, demand adherence to stringent specifications. Manufacturers must demonstrate robust quality control measures, including strict impurity limits (≤0.2%) and controlled moisture content (≤0.5%).

Understanding the chemical properties of this intermediate, such as its pale yellow solid appearance and solubility characteristics, is also vital for R&D scientists and formulation experts. Storage recommendations, typically in a cool, dry, and well-closed container away from moisture and heat, are essential for maintaining its integrity over time. For those in the pharmaceutical research and development sector, sourcing reliable intermediates like (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone from reputable manufacturers is a fundamental step in bringing life-saving medications to market.