Understanding the chemical nuances of synthesis building blocks is crucial for successful research and development in organic chemistry and pharmaceuticals. Fmoc-Sar-OH (CAS: 77128-70-2), a protected derivative of sarcosine, exemplifies this. As a professional manufacturer and supplier of fine chemicals based in China, we are committed to providing high-quality intermediates like Fmoc-Sar-OH that empower scientific advancement. This article explores the key chemical properties and synthesis applications of this important compound.

Fmoc-Sar-OH, chemically identified as N-Fmoc-N-methylglycine, features a fluorenylmethyloxycarbonyl (Fmoc) protecting group attached to the nitrogen of N-methylglycine. The Fmoc group is a cornerstone of the Fmoc/tBu solid-phase peptide synthesis (SPPS) strategy, offering base-labile cleavage that is orthogonal to acid-labile side-chain protecting groups. The sarcosine moiety itself, with its N-methyl substitution, plays a significant role in altering peptide structure and properties. It can introduce conformational rigidity, potentially influence receptor binding, and importantly, confer increased resistance to enzymatic degradation. This latter characteristic is a major driver for its use in peptide drug design.

From a physical and chemical standpoint, Fmoc-Sar-OH is typically supplied as a white to off-white powder. Its molecular formula is C18H17NO4, with a molecular weight of approximately 311.33 g/mol. The melting point is around 115°C, often accompanied by decomposition, indicating its thermal sensitivity and the need for appropriate handling and storage conditions, usually recommended at 2-8°C. When considering where to buy Fmoc-Sar-OH, researchers and procurement specialists must prioritize suppliers who provide comprehensive technical data and guarantee high purity, typically above 95% by HPLC. As a leading manufacturer, we ensure these standards are met for all our products.

The primary application of Fmoc-Sar-OH is as a key building block in the synthesis of peptides containing N-methylated amino acid residues. This is particularly relevant in areas such as medicinal chemistry, where the goal is to develop peptide analogs with improved pharmacological profiles – enhanced stability, bioavailability, or target specificity. It serves as an excellent intermediate for creating peptidomimetics, which can mimic the biological activity of natural peptides while offering superior stability. For companies engaged in custom peptide synthesis or drug discovery, securing a consistent and reliable supply of Fmoc-Sar-OH is a strategic advantage.

We, as a dedicated chemical manufacturer in China, are equipped to meet the demand for high-quality Fmoc-Sar-OH. Our advanced synthesis capabilities and stringent quality control processes ensure that our products are ideal for demanding applications. We invite you to consider us as your primary supplier for this essential peptide synthesis reagent. Contact us today to obtain a quote and a sample of Fmoc-Sar-OH, and discover the difference quality sourcing makes in your chemical research and development endeavors.