In the dynamic field of peptide synthesis, the choice of building blocks significantly dictates the success and efficiency of the process. Among these crucial components, Fmoc-Sar-OH, a protected N-methylglycine derivative, stands out for its unique contributions. As a reputable manufacturer and supplier in China, we understand the critical role such intermediates play in research and pharmaceutical development. This article delves into why Fmoc-Sar-OH (CAS: 77128-70-2) has become an indispensable tool for chemists aiming to synthesize peptides with enhanced properties.

Fmoc-Sar-OH, chemically known as N-Fmoc-N-methylglycine, is characterized by its Fmoc (fluorenylmethyloxycarbonyl) protecting group. This group is essential in solid-phase peptide synthesis (SPPS) as it allows for selective deprotection and coupling steps, ensuring the integrity of the growing peptide chain. The presence of a methyl group on the nitrogen atom of glycine, a feature of sarcosine, confers distinct advantages. Primarily, it imparts increased metabolic stability to the resulting peptides. This is particularly vital in drug development, where peptides are often susceptible to enzymatic degradation in vivo. By incorporating Fmoc-Sar-OH, researchers can create peptidomimetics or peptides that exhibit longer half-lives, thus improving their therapeutic potential.

The chemical properties of Fmoc-Sar-OH make it a versatile reagent. Typically appearing as a white powder, it has a defined melting point (around 115°C with decomposition) and a molecular formula of C18H17NO4. Its solubility in common organic solvents facilitates its integration into various synthesis protocols. For professionals looking to buy Fmoc-Sar-OH, sourcing from a reliable manufacturer like us in China ensures consistent purity and quality, which are paramount for reproducible results in both academic research and industrial applications. Understanding the benefits of this N-methylglycine derivative is key for procurement managers and research scientists.

The applications of Fmoc-Sar-OH extend beyond simple chain elongation. It is instrumental in designing peptides with specific conformational constraints or altered hydrophobicity, influencing their interaction with biological targets. This makes it a valuable component in medicinal chemistry for developing novel therapeutics. When considering your procurement strategy, selecting a dedicated supplier that specializes in high-quality peptide synthesis reagents is crucial. Our commitment as a leading manufacturer means we offer competitive pricing for bulk purchases of Fmoc-Sar-OH, alongside expert support for your project needs.

For those involved in custom peptide synthesis or seeking to optimize their drug discovery pipelines, Fmoc-Sar-OH represents a strategic choice. We invite you to explore our offerings and discover how our high-purity Fmoc-Sar-OH can elevate your research. Contact us today to get a quote and sample, and learn more about how our manufacturing capabilities can meet your demands for this essential peptide building block.