In the realm of organic chemistry and pharmaceutical development, understanding the intrinsic properties of chemical intermediates is fundamental. 4-Chloro-7-methoxyquinoline-6-carboxamide (CAS: 417721-36-9) is a compound that plays a pivotal role in the synthesis of complex pharmaceutical molecules, most notably Lenvatinib. This article aims to elucidate its chemical characteristics, synthesis pathways, and diverse applications, providing valuable insights for researchers and industrial chemists looking to buy or utilize this crucial intermediate.

Chemically, 4-Chloro-7-methoxyquinoline-6-carboxamide is a substituted quinoline derivative. Its structure features a quinoline core with a chlorine atom at the 4-position, a methoxy group at the 7-position, and a carboxamide group at the 6-position. The molecular formula, C11H9ClN2O2, and a molecular weight of 236.65 g/mol, dictate its reactivity and interaction in synthetic processes. Typically presented as a pale yellow to off-white solid, its physical form and purity levels, often exceeding 98% via HPLC, are critical parameters for its intended use.

The synthesis of 4-Chloro-7-methoxyquinoline-6-carboxamide often involves multi-step chemical reactions starting from more basic precursors. One common route described in literature involves the conversion of methyl 4-chloro-7-methoxyquinoline-6-carboxylate to the amide using ammonia under specific reaction conditions. The optimization of these synthetic routes by manufacturers is key to achieving high yields and purity, ensuring a cost-effective supply for downstream applications. As a dedicated chemical manufacturer, we focus on robust synthesis protocols to deliver consistent quality.

The primary application of this compound lies in its function as a direct precursor to Lenvatinib, a vital targeted therapy in oncology. The carboxamide group and the specific substitution pattern on the quinoline ring are essential for building the Lenvatinib molecule. Pharmaceutical companies looking to procure this intermediate for Lenvatinib production will find that reliable suppliers offer it in various quantities, from grams for research to kilograms and metric tons for commercial manufacturing. Its utility also extends to being a valuable scaffold for exploring new drug candidates in medicinal chemistry.

For those engaged in chemical research and development, understanding the compound's chemical behavior, solubility profiles (e.g., slight solubility in DMSO and methanol), and stability requirements is crucial. Proper storage conditions, typically refrigerated and protected from moisture, are recommended to maintain its quality. When considering a purchase, it is advisable to partner with a supplier that provides detailed technical data and demonstrates a commitment to quality assurance. By thoroughly understanding these chemical aspects, scientists and manufacturers can effectively integrate 4-Chloro-7-methoxyquinoline-6-carboxamide into their synthetic strategies, ensuring the successful development and production of life-saving pharmaceuticals.