In the intricate landscape of pharmaceutical manufacturing, the precise synthesis of Active Pharmaceutical Ingredients (APIs) hinges on the quality and availability of their precursor molecules. Among these critical building blocks, 4-Chloro-7-methoxyquinoline-6-carboxamide stands out as an indispensable intermediate in the production of Lenvatinib, a targeted therapy used in the treatment of various advanced cancers. Understanding the properties, synthesis, and sourcing of this compound is paramount for pharmaceutical companies and contract manufacturers.

4-Chloro-7-methoxyquinoline-6-carboxamide, identified by its CAS number 417721-36-9, is a finely tuned organic molecule. Its molecular formula, C11H9ClN2O2, and molecular weight of 236.65 g/mol, underscore its specific role in the Lenvatinib molecular structure. Typically appearing as an off-white to light yellow powder, this intermediate exhibits a high purity, often exceeding 98% as determined by HPLC. This level of purity is not merely a specification but a prerequisite for its use in pharmaceutical synthesis, ensuring that the final API meets stringent regulatory standards for efficacy and safety.

The primary application of 4-Chloro-7-methoxyquinoline-6-carboxamide is its direct utilization in the multi-step synthesis of Lenvatinib Mesylate. Lenvatinib is a potent inhibitor of vascular endothelial growth factor (VEGF) receptors and other tyrosine kinases, making it a vital treatment option for differentiated thyroid cancer, hepatocellular carcinoma, and renal cell carcinoma. The strategic importance of this intermediate means that a stable and reliable supply chain is essential for uninterrupted Lenvatinib production. Pharmaceutical companies looking to buy this critical component often seek experienced manufacturers in China who can guarantee both quality and volume.

For procurement managers and R&D scientists, sourcing high-quality pharmaceutical intermediates like 4-Chloro-7-methoxyquinoline-6-carboxamide involves careful consideration of several factors. These include the supplier's manufacturing capabilities, their adherence to quality management systems (such as ISO certifications), and their ability to provide comprehensive documentation like Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS). Furthermore, competitive pricing and efficient logistics are crucial for managing production costs and timelines. Manufacturers who offer custom synthesis services or can provide bulk quantities at favorable price points are highly sought after.

The chemical properties, including its melting point (often above 205°C with decomposition) and solubility (slightly soluble in DMSO and methanol), are important considerations for handling and processing. Proper storage, typically under inert gas at 2-8°C, is vital to maintain its integrity and efficacy. When seeking to purchase this intermediate, it is advisable to engage with established suppliers who can provide technical support and a transparent sourcing experience. This ensures that your Lenvatinib production pipeline remains robust and efficient, ultimately contributing to the availability of life-saving medications.