For professionals in the pharmaceutical and fine chemical industries, understanding the sourcing and application of key intermediates is crucial. Chloromethyl Isopropyl Carbonate, identified by its CAS number 35180-01-9, is one such compound that plays a pivotal role, particularly in the synthesis of antiviral medications.

This article serves as a comprehensive guide for R&D scientists, procurement managers, and anyone involved in the purchase or utilization of Chloromethyl Isopropyl Carbonate. We will delve into its chemical profile, its critical application as a Tenofovir intermediate, and provide insights into sourcing strategies, including how to buy from reliable manufacturers. Our aim is to equip you with the knowledge to make informed decisions.

Deciphering Chloromethyl Isopropyl Carbonate: Properties and Specifications

Chloromethyl Isopropyl Carbonate (CAS 35180-01-9) is a chemical compound with the molecular formula C5H9ClO3 and a molecular weight of 152.58. It is typically supplied as a clear, colorless to slightly yellow liquid. Its key specifications often include a high purity level, usually ≥99.0% as analyzed by GC. This level of purity is essential for its use in pharmaceutical synthesis, where even minor impurities can significantly impact reaction outcomes and the quality of the final product.

Other important properties include a density around 1.14-1.15 g/cm³ and a refractive index of about 1.41-1.42. The compound's flash point is approximately 48°C. It is important to note that Chloromethyl Isopropyl Carbonate is moisture-sensitive, requiring careful handling and storage, typically under an inert atmosphere in cool, dry conditions to preserve its quality and prevent degradation. Understanding these properties is vital for effective laboratory and production use.

The Critical Link: Chloromethyl Isopropyl Carbonate in Tenofovir Synthesis

The primary and most significant application of Chloromethyl Isopropyl Carbonate is its role as a key intermediate in the manufacturing of Tenofovir. Tenofovir is a vital antiretroviral medication used in the treatment of HIV/AIDS and chronic Hepatitis B. The chemical structure of Chloromethyl Isopropyl Carbonate is strategically designed to undergo specific reactions that are integral to the efficient and successful synthesis of Tenofovir, contributing directly to the availability of this crucial therapy.

For pharmaceutical manufacturers, ensuring a consistent and high-quality supply of this intermediate is paramount. It directly influences the yield, purity, and cost-effectiveness of the final drug product. Researchers in medicinal chemistry may also find it useful in the development of other novel compounds.

Procurement Strategies: Buying from Chinese Manufacturers

When looking to buy Chloromethyl Isopropyl Carbonate, particularly for large-scale pharmaceutical production, partnering with reliable Chinese manufacturers offers distinct advantages. These include competitive pricing, advanced manufacturing capabilities, and a vast chemical supply network. We are a dedicated manufacturer and supplier committed to providing high-purity Chloromethyl Isopropyl Carbonate that meets global pharmaceutical standards.

We encourage procurement professionals to request detailed quotes and product specifications. A transparent supplier will readily provide Certificates of Analysis (CoAs) and technical support. Building a strong relationship with a dependable chemical supplier is key to maintaining an efficient and uninterrupted production process. Contact us to discuss your requirements and to learn how we can be your trusted source for Chloromethyl Isopropyl Carbonate.