In the intricate world of chemical synthesis, understanding the properties and applications of specific compounds is crucial for R&D scientists and production managers alike. Chloromethyl Isopropyl Carbonate (CAS 35180-01-9) is one such compound that holds significant importance, particularly within the pharmaceutical sector as a key intermediate.

This article aims to provide a comprehensive overview of Chloromethyl Isopropyl Carbonate, covering its physical and chemical characteristics, its primary applications, and effective strategies for sourcing this vital chemical from reliable manufacturers. For businesses seeking to buy this product, knowledge of its attributes and the supply landscape is essential.

Chemical Profile and Specifications

Chloromethyl Isopropyl Carbonate, identified by CAS number 35180-01-9, presents itself as a clear liquid, often colorless to a slight yellow hue. Its molecular formula is C5H9ClO3, with a corresponding molecular weight of 152.58. Key physical properties include a density of approximately 1.14-1.15 g/cm³ and a refractive index around 1.41-1.42. The compound has a flash point of approximately 48°C, indicating moderate flammability.

Crucially for its application, the purity of Chloromethyl Isopropyl Carbonate is typically specified as ≥99.0% (by GC). Other important specifications often include moisture content (≤0.5%) and limits on individual and total impurities, ensuring its suitability for demanding synthesis processes. Due to its sensitivity to moisture, proper storage conditions, such as an inert atmosphere at 2-8°C, are recommended.

Applications in Pharmaceutical Synthesis

The primary and most recognized application of Chloromethyl Isopropyl Carbonate is its role as a critical intermediate in the synthesis of Tenofovir. Tenofovir is a potent antiviral medication used globally to treat HIV/AIDS and chronic Hepatitis B infections. The chemical structure of Chloromethyl Isopropyl Carbonate is tailor-made to facilitate the specific reactions required to build the complex Tenofovir molecule.

For pharmaceutical companies and contract manufacturing organizations (CMOs), securing a consistent and high-quality supply of this intermediate is vital for maintaining production efficiency and ensuring the therapeutic efficacy of the final drug product. Researchers in organic synthesis may also find it useful for incorporating specific functional groups into various organic molecules.

Sourcing Strategies and Supplier Selection

When looking to buy Chloromethyl Isopropyl Carbonate, particularly in bulk, strategic sourcing is key. Identifying reputable manufacturers and suppliers, especially those based in China, can offer significant advantages in terms of cost and availability. It is advisable to partner with suppliers who can provide detailed Certificates of Analysis (CoA), demonstrate robust quality control measures, and offer competitive pricing.

Procurement managers should evaluate potential suppliers based on their production capacity, adherence to regulatory standards, and customer service. Requesting samples for in-house testing is a standard practice to verify purity and suitability for specific applications. Building a relationship with a reliable manufacturer ensures a stable supply chain, mitigating risks associated with production delays or quality issues.

For your industrial or pharmaceutical needs, consider us as your preferred supplier. We provide high-purity Chloromethyl Isopropyl Carbonate with comprehensive technical support. Request a quote today to explore our offerings and discuss your specific requirements for this essential chemical intermediate.