For researchers delving into the complex world of ion channels, selecting the right pharmacological tools is paramount. Transient Receptor Potential Canonical (TRPC) channels, particularly TRPC5, play critical roles in numerous physiological processes, making them targets for conditions ranging from neurological disorders to cardiovascular diseases. When seeking to investigate these channels, understanding the properties of available inhibitors is key.

Clemizole Hydrochloride (CAS 1163-36-6) has emerged as a significant player in TRPC channel research. It is recognized as a potent and selective inhibitor of TRPC5 channels, demonstrating efficacy in blocking TRPC5 currents and calcium (Ca2+) entry in the low micromolar range. Its selectivity over other TRPC subtypes, such as TRPC4β, TRPC3, and TRPC6, makes it an invaluable asset for precise experimental design. This makes Clemizole Hydrochloride a prime candidate for purchase when high specificity is required.

Beyond its role as a TRPC5 inhibitor, Clemizole Hydrochloride also exhibits activity as an H1 histamine receptor antagonist. This dual functionality opens doors for research into conditions where both pathways are implicated, such as inflammatory responses and certain allergic reactions. Furthermore, preliminary studies have indicated its potential as an anticonvulsant in models of Dravet syndrome, highlighting its broad therapeutic research potential.

When procuring research chemicals like Clemizole Hydrochloride, the quality and reliability of the manufacturer are critical. As a dedicated supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-purity (≥97%) Clemizole Hydrochloride, ensuring that your experiments yield accurate and reproducible results. We understand the importance of consistent quality for scientific advancement and are here to support your procurement needs. Whether you are looking to buy for laboratory use or require bulk quantities, consulting with a trusted manufacturer like us can streamline your research process and guarantee product integrity.