For professionals in the chemical industry, understanding the synthesis, properties, and safe handling of reactive intermediates is crucial for efficient and secure operations. Cyclopropanecarbonyl Chloride, identified by CAS number 4023-34-1, is a prime example of such a compound. This article delves into the synthesis pathways, key properties, and essential safety considerations for this valuable chemical building block. Synthesis Pathways: While specific proprietary synthesis routes can vary between manufacturers, Cyclopropanecarbonyl Chloride is typically synthesized from cyclopropanecarboxylic acid. The conversion of a carboxylic acid to an acid chloride is a standard organic chemistry transformation. Common reagents used for this purpose include thionyl chloride (SOCl2) or oxalyl chloride ((COCl)2), often in the presence of a catalytic amount of dimethylformamide (DMF). The reaction involves the replacement of the hydroxyl group (-OH) of the carboxylic acid with a chlorine atom (-Cl). The resulting product, Cyclopropanecarbonyl Chloride, is then purified, often by distillation, to achieve the required purity levels for its intended applications. Key Properties and Reactivity: As previously noted, Cyclopropanecarbonyl Chloride (C4H5ClO) is a liquid at room temperature, appearing clear and colorless to slightly yellow. Its boiling point of 119°C and density of 1.152 g/mL are important physical parameters for handling and storage. Its primary chemical characteristic is its high reactivity as an acylating agent. The electron-withdrawing chlorine atom makes the carbonyl carbon highly electrophilic, readily undergoing nucleophilic acyl substitution reactions. This makes it an excellent reagent for esterification, amidation, and Friedel-Crafts acylation reactions. Safety Considerations: Given its reactive nature, Cyclopropanecarbonyl Chloride necessitates strict safety protocols. As a moisture-sensitive compound, it reacts with water to produce corrosive hydrochloric acid fumes. Therefore, it must be stored in tightly sealed containers under anhydrous conditions, preferably in a cool environment (0-6°C). When handling, personal protective equipment (PPE) is paramount. This includes chemical-resistant gloves (e.g., nitrile or neoprene), safety goggles or a face shield to protect the eyes from splashes and vapors, and protective clothing to prevent skin contact. Work should be conducted in a well-ventilated area, preferably a fume hood, to minimize inhalation of vapors. In case of skin or eye contact, immediate and thorough flushing with water is essential, followed by medical attention. Fire hazards should also be considered. The compound has a flash point of 74°F (23°C), classifying it as a flammable liquid. Appropriate fire suppression measures, such as dry chemical or carbon dioxide extinguishers, should be readily available. It is important to avoid ignition sources when working with or storing this chemical. Sourcing and Quality Assurance: For businesses looking to buy Cyclopropanecarbonyl Chloride, partnering with reputable manufacturers such as NINGBO INNO PHARMCHEM CO.,LTD. is key. We ensure rigorous quality control throughout the synthesis and purification process to deliver products that meet high purity standards. Understanding the safety data sheet (SDS) provided by the supplier is essential for any user. In conclusion, Cyclopropanecarbonyl Chloride is a powerful synthetic tool, but its effective and safe utilization demands a thorough understanding of its properties and handling requirements. By adhering to proper safety protocols and sourcing from reliable manufacturers, chemical professionals can confidently integrate this intermediate into their innovative synthesis projects.