Cyclopropanecarbonyl Chloride, identified by its CAS number 4023-34-1, is a compound that holds significant importance in the realm of organic chemistry and material science. As a fine chemical, its unique structural features and reactivity make it a sought-after intermediate for a multitude of synthesis processes. This article aims to provide a detailed overview of its properties and the diverse applications it serves, emphasizing its value to researchers and industrial manufacturers. Physical and Chemical Properties: Cyclopropanecarbonyl Chloride (C4H5ClO) is a derivative of cyclopropanecarboxylic acid. It typically appears as a clear, colorless to slightly yellow liquid. Its density is recorded at 1.152 g/mL at 25°C, and it possesses a boiling point of approximately 119°C. A key characteristic of this compound, like many acid chlorides, is its sensitivity to moisture. Exposure to water leads to hydrolysis, forming cyclopropanecarboxylic acid and hydrochloric acid. This property dictates the need for anhydrous conditions during its handling, storage, and use in synthesis. The refractive index is noted at n20/D 1.452, a standard measurement for liquid compounds. Key Applications: 1. Pharmaceutical Intermediates: The cyclopropane ring is a recurring motif in many biologically active molecules. Cyclopropanecarbonyl Chloride serves as an essential building block for introducing this moiety into drug candidates. It is employed in the synthesis of active pharmaceutical ingredients (APIs) and their precursors, contributing to the development of therapeutics with improved efficacy and metabolic profiles. Pharmaceutical companies often seek reliable sources to buy this compound for R&D and production. 2. Agrochemical Synthesis: In the agricultural sector, this chemical intermediate is utilized in the synthesis of various crop protection agents, including insecticides, herbicides, and fungicides. The cyclopropane structure can enhance the potency and selectivity of these agrochemicals, leading to more effective pest and weed control while potentially offering better environmental characteristics. Manufacturers in this field rely on consistent supply from specialized suppliers. 3. Organic Synthesis and Fine Chemicals: Beyond pharmaceuticals and agrochemicals, Cyclopropanecarbonyl Chloride is a versatile reagent in general organic synthesis. It is used to create specialized esters, amides, and other derivatives that find applications in materials science, flavors, fragrances, and other fine chemical industries. Its high reactivity as an acylating agent makes it a valuable tool for chemists in both academic research and industrial development. Sourcing and Supply: When considering the purchase of Cyclopropanecarbonyl Chloride, it is vital to partner with reputable manufacturers and suppliers. Factors such as purity, batch consistency, and reliable delivery are crucial for successful projects. Companies like NINGBO INNO PHARMCHEM CO.,LTD. specialize in providing high-quality fine chemicals and offer competitive pricing, especially for bulk orders. Understanding the logistical aspects, including payment terms and shipping options, is also important for efficient procurement. In conclusion, Cyclopropanecarbonyl Chloride is a critical and versatile chemical intermediate. Its unique structural attributes and reactivity as an acylating agent make it indispensable in the synthesis of advanced materials and bioactive compounds. For those looking to procure this essential chemical, seeking out experienced manufacturers who can guarantee quality and provide excellent customer service is the surest path to success.